Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2878900..2879524 Replicon chromosome
Accession NZ_CP052861
Organism Pseudomonas sp. ADAK7

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HKK53_RS13400 Protein ID WP_169371212.1
Coordinates 2878900..2879079 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HKK53_RS13405 Protein ID WP_169371213.1
Coordinates 2879117..2879524 (+) Length 136 a.a.

Genomic Context

HKK53_RS13375HKK53_RS13380HKK53_RS13385HKK53_RS13390HKK53_RS13400HKK53_RS13405HKK53_RS13410HKK53_RS13415HKK53_RS13425HKK53_RS13430HKK53_RS13420
Location: 2874726..2876213 (1488 bp)
Type: Others
Protein ID: WP_169371208.1
Location: 2876206..2876424 (219 bp)
Type: Others
Protein ID: WP_169371209.1
Location: 2876459..2877151 (693 bp)
Type: Others
Protein ID: WP_169371210.1
Location: 2877464..2878348 (885 bp)
Type: Others
Protein ID: WP_169371211.1
Location: 2878900..2879079 (180 bp)
Type: Toxin
Protein ID: WP_169371212.1
Location: 2879117..2879524 (408 bp)
Type: Antitoxin
Protein ID: WP_169371213.1
Location: 2880002..2880265 (264 bp)
Type: Others
Protein ID: WP_123507545.1
Location: 2880645..2881373 (729 bp)
Type: Others
Protein ID: WP_169371214.1
Location: 2882619..2883122 (504 bp)
Type: Others
Protein ID: WP_169371216.1
Location: 2883246..2883785 (540 bp)
Type: Others
Protein ID: WP_169371217.1
Location: 2881454..2882224 (771 bp)
Type: Others
Protein ID: WP_169371215.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HKK53_RS133752874726..2876213+1488WP_169371208.1sensor domain-containing diguanylate cyclase-
HKK53_RS133802876206..2876424+219WP_169371209.1cysteine-rich CWC family protein-
HKK53_RS133852876459..2877151+693WP_169371210.1pseudouridine synthase-
HKK53_RS133902877464..2878348+885WP_169371211.1alpha/beta hydrolase-
HKK53_RS134002878900..2879079+180WP_169371212.1type II toxin-antitoxin system HicA family toxinToxin
HKK53_RS134052879117..2879524+408WP_169371213.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
HKK53_RS134102880002..2880265+264WP_123507545.1short-chain dehydrogenase-
HKK53_RS134152880645..2881373+729WP_169371214.1class I SAM-dependent methyltransferase-
HKK53_RS134202881454..2882224-771WP_169371215.1trans-aconitate 2-methyltransferase-
HKK53_RS134252882619..2883122+504WP_169371216.1inclusion body family protein-
HKK53_RS134302883246..2883785+540WP_169371217.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6723.00 Da        Isoelectric Point: 11.4113

>T155660 WP_169371212.1 NZ_CP052861:2878900-2879079 [Pseudomonas sp. ADAK7]
VNSRFLISQIVADGWYLVRIRGSHHHFKHPTKPGLVTVPHPKKDLLKKTAMSILQQALL

Download         Length: 180 bp

>T155660 NZ_CP068810:4564676-4564933 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGCCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14662.68 Da        Isoelectric Point: 4.4904

>AT155660 WP_169371213.1 NZ_CP052861:2879117-2879524 [Pseudomonas sp. ADAK7]
MLYPISISMGDDEHAWGVEVPDIPGCFSAGEDLDDAMAMAREAIEGHFEILAEDGSPIPPANKVTLHAANPKYAGCTWAL
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQG

Download         Length: 408 bp

>AT155660 NZ_CP068810:4564945-4565496 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCGACCTTCAAAGGAGAAATGGATTCACCGCTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References