Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2878900..2879524 Replicon chromosome
Accession NZ_CP052861
Organism Pseudomonas sp. ADAK7

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HKK53_RS13400 Protein ID WP_169371212.1
Coordinates 2878900..2879079 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HKK53_RS13405 Protein ID WP_169371213.1
Coordinates 2879117..2879524 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKK53_RS13375 2874726..2876213 + 1488 WP_169371208.1 sensor domain-containing diguanylate cyclase -
HKK53_RS13380 2876206..2876424 + 219 WP_169371209.1 cysteine-rich CWC family protein -
HKK53_RS13385 2876459..2877151 + 693 WP_169371210.1 pseudouridine synthase -
HKK53_RS13390 2877464..2878348 + 885 WP_169371211.1 alpha/beta hydrolase -
HKK53_RS13400 2878900..2879079 + 180 WP_169371212.1 type II toxin-antitoxin system HicA family toxin Toxin
HKK53_RS13405 2879117..2879524 + 408 WP_169371213.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HKK53_RS13410 2880002..2880265 + 264 WP_123507545.1 short-chain dehydrogenase -
HKK53_RS13415 2880645..2881373 + 729 WP_169371214.1 class I SAM-dependent methyltransferase -
HKK53_RS13420 2881454..2882224 - 771 WP_169371215.1 trans-aconitate 2-methyltransferase -
HKK53_RS13425 2882619..2883122 + 504 WP_169371216.1 inclusion body family protein -
HKK53_RS13430 2883246..2883785 + 540 WP_169371217.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6723.00 Da        Isoelectric Point: 11.4113

>T155660 WP_169371212.1 NZ_CP052861:2878900-2879079 [Pseudomonas sp. ADAK7]
VNSRFLISQIVADGWYLVRIRGSHHHFKHPTKPGLVTVPHPKKDLLKKTAMSILQQALL

Download         Length: 180 bp

>T155660 NZ_CP068810:4564676-4564933 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGCCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14662.68 Da        Isoelectric Point: 4.4904

>AT155660 WP_169371213.1 NZ_CP052861:2879117-2879524 [Pseudomonas sp. ADAK7]
MLYPISISMGDDEHAWGVEVPDIPGCFSAGEDLDDAMAMAREAIEGHFEILAEDGSPIPPANKVTLHAANPKYAGCTWAL
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQG

Download         Length: 408 bp

>AT155660 NZ_CP068810:4564945-4565496 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCGACCTTCAAAGGAGAAATGGATTCACCGCTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References