Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2571209..2571825 Replicon chromosome
Accession NZ_CP052861
Organism Pseudomonas sp. ADAK7

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HKK53_RS12005 Protein ID WP_163909086.1
Coordinates 2571613..2571825 (-) Length 71 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HKK53_RS12000 Protein ID WP_169370991.1
Coordinates 2571209..2571613 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKK53_RS11980 2567003..2567998 + 996 WP_149656989.1 sulfate ABC transporter substrate-binding protein -
HKK53_RS11985 2568210..2568839 - 630 WP_178117451.1 hypothetical protein -
HKK53_RS11990 2569074..2570279 + 1206 WP_169370989.1 MFS transporter -
HKK53_RS11995 2570310..2571149 + 840 WP_169370990.1 hypothetical protein -
HKK53_RS12000 2571209..2571613 - 405 WP_169370991.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HKK53_RS12005 2571613..2571825 - 213 WP_163909086.1 type II toxin-antitoxin system HicA family toxin Toxin
HKK53_RS12010 2572048..2572704 + 657 WP_169370992.1 AhpC/TSA family protein -
HKK53_RS12015 2572753..2573472 + 720 WP_169370993.1 SDR family oxidoreductase -
HKK53_RS12020 2573632..2574519 + 888 WP_169370994.1 LysR family transcriptional regulator -
HKK53_RS12025 2574528..2574686 - 159 WP_169370995.1 hypothetical protein -
HKK53_RS12030 2574687..2575091 - 405 WP_169370996.1 hypothetical protein -
HKK53_RS12035 2575106..2576305 - 1200 WP_169370997.1 c-type cytochrome biogenesis protein CcmI -
HKK53_RS12040 2576298..2576771 - 474 WP_169370998.1 cytochrome c-type biogenesis protein CcmH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 7952.14 Da        Isoelectric Point: 9.9104

>T155659 WP_163909086.1 NZ_CP052861:c2571825-2571613 [Pseudomonas sp. ADAK7]
VQSRLLIKELEEAGWTLDRVTGSHHIFTHRYNPYTIPVPHPKKDLPIGTVKSIRRRAGLYCPPASYTGDP

Download         Length: 213 bp

>T155659 NZ_CP068810:c4502510-4502301 [Escherichia coli]
ATGGTTGATTATCCAAAACGTGATGCTATTTCCAACATCAACGCTATAATTGTAGATACATTTTTGTATATACAATTAGG
GATGGCAACTATGCCAATGGAGTTTGAATGGAATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTG
AAGATGCGGTGTTAGTGCTTGATGATCCACAACGAACGGAGCCGCTATGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14771.80 Da        Isoelectric Point: 4.3937

>AT155659 WP_169370991.1 NZ_CP052861:c2571613-2571209 [Pseudomonas sp. ADAK7]
MQYPICIEWGDENTAIGIQIPDIPGAVTAGDTFEDAYNAAIEVAHVMLQEIAADGEPIPMPTSAAAHRGNPEFVDMGWGM
LELDIAPYMGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLVRH

Download         Length: 405 bp

>AT155659 NZ_CP068810:c4502304-4502002 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGTGCTGGCGAA
CAAATTCGACGAGGATATTGATTACAGCGACATCCCATCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References