Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1566583..1567176 Replicon chromosome
Accession NZ_CP052860
Organism Pseudomonas sp. ADAK13

Toxin (Protein)


Gene name relE Uniprot ID A0A7Z2XKX9
Locus tag HKK54_RS07480 Protein ID WP_010173995.1
Coordinates 1566583..1566885 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A246FYK1
Locus tag HKK54_RS07485 Protein ID WP_010173992.1
Coordinates 1566889..1567176 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKK54_RS07455 1561631..1562257 - 627 WP_169386478.1 precorrin-8X methylmutase -
HKK54_RS07460 1562250..1563551 - 1302 WP_169386479.1 precorrin-3B synthase -
HKK54_RS07465 1563647..1564852 + 1206 WP_169386480.1 precorrin-6y C5,15-methyltransferase (decarboxylating) subunit CbiE -
HKK54_RS07470 1564849..1565568 + 720 WP_169386481.1 cobalt-precorrin-6A reductase -
HKK54_RS07475 1565690..1565941 - 252 WP_010173996.1 hypothetical protein -
HKK54_RS07480 1566583..1566885 + 303 WP_010173995.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HKK54_RS07485 1566889..1567176 + 288 WP_010173992.1 putative addiction module antidote protein Antitoxin
HKK54_RS07490 1567274..1567669 + 396 WP_169386482.1 DUF2946 domain-containing protein -
HKK54_RS07495 1567716..1568198 + 483 WP_010173988.1 copper chaperone PCu(A)C -
HKK54_RS07500 1568263..1568634 + 372 WP_169386483.1 DUF2946 domain-containing protein -
HKK54_RS07505 1568728..1570800 + 2073 WP_169386484.1 TonB-dependent copper receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(4-93)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11560.11 Da        Isoelectric Point: 9.4639

>T155656 WP_010173995.1 NZ_CP052860:1566583-1566885 [Pseudomonas sp. ADAK13]
MIHFKKSEHFLEWLDSLNNKPARARVLARLDNAQSGNFGDCETVGNGVSEMRIHYGPGYRVYFTRREEVVYLLLIGGDKS
TQKRDIQRAKQIAADFEKKE

Download         Length: 303 bp

>T155656 NZ_CP068810:3882838-3883056 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10368.74 Da        Isoelectric Point: 4.3757

>AT155656 WP_010173992.1 NZ_CP052860:1566889-1567176 [Pseudomonas sp. ADAK13]
MTEFTDFDIAEHLKTPEDMAEYLEACFEEDTGDGLLIRSALNNIARAQGMTQVARDAGLGRESLYKALSSTGNPEFATIM
KVMKALGLKLHATAD

Download         Length: 288 bp

>AT155656 NZ_CP068810:3882438-3882812 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z2XKX9

Antitoxin

Source ID Structure
AlphaFold DB A0A246FYK1

References