Detailed information of TA system TA155655

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 237075..237689
• Replicon: chromosome
• Accession: NZ_CP052860
• Organism: Pseudomonas sp. ADAK13

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HKK54_RS01035
• Protein ID: WP_169385931.1
• Coordinates: 237501..237689 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A246FXS3
• Locus tag: HKK54_RS01030
• Protein ID: WP_010166194.1
• Coordinates: 237075..237479 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HKK54_RS01010	232974..233798	+	825	WP_010166204.1	ion transporter	-
HKK54_RS01015	233904..234908	+	1005	WP_010166202.1	sulfate ABC transporter substrate-binding protein	-
HKK54_RS01020	235079..235693	-	615	WP_169385929.1	hypothetical protein	-
HKK54_RS01025	235872..237068	+	1197	WP_169385930.1	MFS transporter	-
HKK54_RS01030	237075..237479	-	405	WP_010166194.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HKK54_RS01035	237501..237689	-	189	WP_169385931.1	type II toxin-antitoxin system HicA family toxin	Toxin
HKK54_RS01040	237906..238784	+	879	WP_169385932.1	LysR family transcriptional regulator	-
HKK54_RS01045	238788..239897	-	1110	WP_169385933.1	cytochrome P450	-
HKK54_RS01050	239972..240658	+	687	WP_169385934.1	metalloregulator ArsR/SmtB family transcription factor	-
HKK54_RS01055	240698..241447	-	750	WP_169385935.1	phosphonate metabolism protein PhnP	-
HKK54_RS01060	241438..242001	-	564	WP_169385936.1	phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7168.33 Da
• Isoelectric Point: 11.2000

>T155655 WP_169385931.1 NZ_CP052860:c237689-237501 [Pseudomonas sp. ADAK13]
VQSRLLIKELQEAGWVLDRVTGSHHLFTHRYNPYTIPVPHPKKDLSLGTVRSIRKRAGLFSF

Nucleotide

• Length: 189 bp

>T155655 NZ_CP068810:3479924-3480310 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14818.91 Da
• Isoelectric Point: 4.5106

>AT155655 WP_010166194.1 NZ_CP052860:c237479-237075 [Pseudomonas sp. ADAK13]
MQYPICIEWGDDFVATGIQIPDIPGAVTAGDSFEEAYNAAVEVAHIMLQEIAAEGRVIPMPTSVAAHHDNEEYAGMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHKVKSRSSFLADAALEKLVRL

Nucleotide

• Length: 405 bp

>AT155655 NZ_CP068810:3480300-3480629 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A246FXS3