Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5027604..5028243 Replicon chromosome
Accession NZ_CP052859
Organism Pseudomonas sp. ADAK18

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HKK55_RS22820 Protein ID WP_169356679.1
Coordinates 5028061..5028243 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HKK55_RS22815 Protein ID WP_169356678.1
Coordinates 5027604..5028005 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKK55_RS22795 5023013..5024656 - 1644 WP_169356674.1 phosphotransferase -
HKK55_RS22800 5024818..5026101 - 1284 WP_169356675.1 amidase -
HKK55_RS22805 5026112..5026537 - 426 WP_169356676.1 VOC family protein -
HKK55_RS22810 5026651..5027523 + 873 WP_169356677.1 LysR family transcriptional regulator -
HKK55_RS22815 5027604..5028005 - 402 WP_169356678.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HKK55_RS22820 5028061..5028243 - 183 WP_169356679.1 type II toxin-antitoxin system HicA family toxin Toxin
HKK55_RS22825 5028482..5030842 - 2361 WP_169356680.1 glucose/quinate/shikimate family membrane-bound PQQ-dependent dehydrogenase -
HKK55_RS22830 5031039..5031950 + 912 WP_169356681.1 sugar ABC transporter substrate-binding protein -
HKK55_RS22835 5032000..5032482 + 483 WP_169356682.1 Lrp/AsnC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6625.75 Da        Isoelectric Point: 10.9062

>T155653 WP_169356679.1 NZ_CP052859:c5028243-5028061 [Pseudomonas sp. ADAK18]
MRSREVIDLLLVDGWFEVAVKGGHHQFKHSTKPGRVTVPHPKSEIAKGTLHSILKSAGLK

Download         Length: 183 bp

>T155653 NZ_CP068810:3087705-3087812 [Escherichia coli]
ATGACGCTCACGCAGTTTGCCATGACTTTCTGGCACGACTTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14553.27 Da        Isoelectric Point: 4.4306

>AT155653 WP_169356678.1 NZ_CP052859:c5028005-5027604 [Pseudomonas sp. ADAK18]
MKFPVVVHKDADSDYSVTVPDVPGCFSAGTSFSEALDNVREALALHLEGLVADEEALPQAQEVDAHLENPDFTGGVWAVI
DFDLTPYLGKSVRFNASLPEHLLSRIDERVQKDHRYASRSGFLATAALRELAV

Download         Length: 402 bp

>AT155653 NZ_CP068810:c3087655-3087592 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References