Detailed information of TA system TA155652

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3968082..3968718
• Replicon: chromosome
• Accession: NZ_CP052859
• Organism: Pseudomonas sp. ADAK18

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HKK55_RS17870
• Protein ID: WP_169355884.1
• Coordinates: 3968082..3968486 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HKK55_RS17875
• Protein ID: WP_169355885.1
• Coordinates: 3968479..3968718 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HKK55_RS17850	3964427..3964699	+	273	WP_155586207.1	DUF2790 domain-containing protein	-
HKK55_RS17855	3965180..3966430	+	1251	WP_169355882.1	ribonucleotide-diphosphate reductase subunit beta	-
HKK55_RS17860	3966614..3967327	+	714	Protein_3506	HNH endonuclease	-
HKK55_RS17865	3967399..3968040	+	642	WP_169355883.1	HAD-IB family hydrolase	-
HKK55_RS17870	3968082..3968486	-	405	WP_169355884.1	type II toxin-antitoxin system VapC family toxin	Toxin
HKK55_RS17875	3968479..3968718	-	240	WP_169355885.1	antitoxin	Antitoxin
HKK55_RS17880	3969096..3970055	-	960	WP_169355886.1	LysR family transcriptional regulator	-
HKK55_RS17885	3970284..3971711	+	1428	WP_169355887.1	argininosuccinate lyase	-
HKK55_RS17890	3971930..3972808	+	879	WP_169355888.1	amino acid ABC transporter permease	-
HKK55_RS17895	3972833..3973597	+	765	WP_169355889.1	amino acid ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (7-54)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15024.23 Da
• Isoelectric Point: 7.4661

>T155652 WP_169355884.1 NZ_CP052859:c3968486-3968082 [Pseudomonas sp. ADAK18]
MIKYMLDTNIVIYIIKRRPIEVLDKFNANVGRMAISSITLAELMHGAEKSQQVEKNTRAVEDFTSRLDVIHYDDKAAFHY
GSIRSDLEKKGTPIGVNDLHIAGHARSSGLVLVTNNEGEFNRVKGLIVENWIAA

Nucleotide

• Length: 405 bp

>T155652 NZ_CP068810:3087170-3087277 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8943.87 Da
• Isoelectric Point: 4.1546

>AT155652 WP_169355885.1 NZ_CP052859:c3968718-3968479 [Pseudomonas sp. ADAK18]
MSTGTVFTNNRTQNIRIPADMRFPAGVKTVEVRAVGRELIISPIENTWDSFFLASESVSDDFMAERADQAQQERESFDD

Nucleotide

• Length: 240 bp

>AT155652 NZ_CP068810:c3087123-3087057 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT