Detailed information of TA system TA155651

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA(toxin)
• Location: 3154920..3155524
• Replicon: chromosome
• Accession: NZ_CP052859
• Organism: Pseudomonas sp. ADAK18

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HKK55_RS13970
• Protein ID: WP_169355221.1
• Coordinates: 3154920..3155171 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HKK55_RS13975
• Protein ID: WP_169355222.1
• Coordinates: 3155168..3155524 (+)
• Length: 119 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HKK55_RS13970	3154920..3155171	+	252	WP_169355221.1	type II toxin-antitoxin system HicA family toxin	Toxin
HKK55_RS13975	3155168..3155524	+	357	WP_169355222.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HKK55_RS13980	3155525..3156697	-	1173	WP_169355223.1	MFS transporter	-
HKK55_RS13985	3156811..3158331	-	1521	WP_169355224.1	multidrug efflux MFS transporter	-
HKK55_RS13990	3158321..3159478	-	1158	WP_169355225.1	HlyD family secretion protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-76)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9510.09 Da
• Isoelectric Point: 10.2601

>T155651 WP_169355221.1 NZ_CP052859:3154920-3155171 [Pseudomonas sp. ADAK18]
VSKNEKLLAKLLNEQMAFTWPELVTLLRRLGYTQIEGAGSRVKFDKGDPSAMITLHKPHPGNELKHYIRRQIIEQLKSGD
LIQ

Nucleotide

• Length: 252 bp

>T155651 NZ_CP068810:c2833891-2833715 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGCGTCACCCCAGCGAAGAGATTAAAGAACCATTGCGTAAAGCCATTCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 119 a.a.
• Molecular weight: 12863.54 Da
• Isoelectric Point: 6.4803

>AT155651 WP_169355222.1 NZ_CP052859:3155168-3155524 [Pseudomonas sp. ADAK18]
VNNQLKHNGYIGSIEASIEDNCLFGKLLFIKALVSYEGKTVAELEAAFRDAVDDYLDTCHSLGQTPEKPCKGSFNVRVGH
DLHLAAALAATRQKVTLNDLTRQALNEFLQHHGAVVTG

Nucleotide

• Length: 357 bp

>AT155651 NZ_CP068810:c2833669-2833253 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATCAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAAAT
TACTCGCTTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA