Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2908639..2910344 Replicon chromosome
Accession NZ_CP052859
Organism Pseudomonas sp. ADAK18

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag HKK55_RS12975 Protein ID WP_169355053.1
Coordinates 2908639..2909514 (+) Length 292 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag HKK55_RS12980 Protein ID WP_169355054.1
Coordinates 2909511..2910344 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKK55_RS12945 2903783..2904181 - 399 WP_169355047.1 cytidine deaminase -
HKK55_RS12950 2904629..2905480 + 852 WP_169355048.1 ABC transporter ATP-binding protein -
HKK55_RS12955 2905520..2906512 + 993 WP_169355049.1 ABC transporter substrate-binding protein -
HKK55_RS12960 2906541..2907317 + 777 WP_169355050.1 ABC transporter permease -
HKK55_RS12965 2907314..2908081 + 768 WP_169355051.1 SDR family oxidoreductase -
HKK55_RS12970 2908095..2908634 + 540 WP_169355052.1 cupin domain-containing protein -
HKK55_RS12975 2908639..2909514 + 876 WP_169355053.1 alpha/beta hydrolase Toxin
HKK55_RS12980 2909511..2910344 + 834 WP_169355054.1 IclR family transcriptional regulator Antitoxin
HKK55_RS12985 2910346..2911143 + 798 WP_169355055.1 SDR family oxidoreductase -
HKK55_RS12990 2911136..2912818 + 1683 WP_169355056.1 thiamine pyrophosphate-binding protein -
HKK55_RS12995 2912829..2913632 + 804 WP_169355057.1 aspartate dehydrogenase -
HKK55_RS13000 2913643..2915139 + 1497 WP_169355058.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(45-275)

Antitoxin

Transcription regulator IclR, C-terminal

(134-256)


Sequences

Toxin        


Download         Length: 292 a.a.        Molecular weight: 31044.62 Da        Isoelectric Point: 7.4872

>T155650 WP_169355053.1 NZ_CP052859:2908639-2909514 [Pseudomonas sp. ADAK18]
MLPSVDHTPLTATLEARLVADFPQRTLTIDGGRQALRECGSGPAIVLLHGIGSGAASWLQVAQQLAPGARVIAWDAPGYG
DSTPLEDLAPKAEAYAQRLLQLLDGLHIEHCVLVGHSLGALTAVAFARLHANRVSRLVLISPARGYGDPSRSQQRQEVRT
KRLRSLEQVGIQGNAEQRSAHMVSAKASPQALAWVRWNMARLNPDGYRQAIELLCGDDLLRHAPLSMPCEVHCGQDDGIT
PPEGCLPLAKALGAHLSLIADAGHASPIEQPLVVAGRLAFAIKESLTGRTL

Download         Length: 876 bp

>T155650 NZ_CP068810:2728805-2730127 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAATGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAACCGTTATGCCAGACCGTTATCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
TGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTGCCGGACGCAGAAATCATTAAAGCGGGGAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTGTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTATTGGGTGGCGCAGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGGTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTTCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGGCCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30794.28 Da        Isoelectric Point: 6.7540

>AT155650 WP_169355054.1 NZ_CP052859:2909511-2910344 [Pseudomonas sp. ADAK18]
MNDSDLLKDAQDKYIVPGLERGLLLLCEFTRRNRTLTAPELARRLALPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLR
LGFEYLASLELTELGQPLLARLCDRLNYPSNLVVRDGRSIVYVAKVSPPSVFSSAVNVGTRLPAHATVLGRILLEDLSLT
ELRELYPEEHLEQHSECTPKTVMELFNMVQADRQRGFVSGEGFFESAISTVAAPVRDQSGRIAAALGVTIPTTQIGHVNF
QELLSQVRRSADELSHLLNYNGGAHDGQPRVTALMRD

Download         Length: 834 bp

>AT155650 NZ_CP068810:2728539-2728805 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGTCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TGACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References