Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 707898..708481 Replicon chromosome
Accession NZ_CP052859
Organism Pseudomonas sp. ADAK18

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HKK55_RS03210 Protein ID WP_169353334.1
Coordinates 708200..708481 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag HKK55_RS03205 Protein ID WP_169353333.1
Coordinates 707898..708197 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKK55_RS03180 703203..703613 - 411 WP_169353328.1 type II toxin-antitoxin system HicB family antitoxin -
HKK55_RS03185 703744..704652 - 909 WP_169353329.1 LysR family transcriptional regulator -
HKK55_RS03190 704908..706071 + 1164 WP_169353330.1 MFS transporter -
HKK55_RS03195 706172..707398 + 1227 WP_169353331.1 MFS transporter -
HKK55_RS03200 707395..707847 + 453 WP_169353332.1 GNAT family N-acetyltransferase -
HKK55_RS03205 707898..708197 - 300 WP_169353333.1 putative addiction module antidote protein Antitoxin
HKK55_RS03210 708200..708481 - 282 WP_169353334.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HKK55_RS03220 709043..709927 - 885 WP_169353335.1 alpha/beta hydrolase -
HKK55_RS03225 710234..710926 - 693 WP_169353336.1 pseudouridine synthase -
HKK55_RS03230 710926..711138 - 213 WP_169353337.1 cysteine-rich CWC family protein -
HKK55_RS03235 711372..711737 + 366 WP_169353338.1 hypothetical protein -
HKK55_RS03240 711899..712333 + 435 WP_169353339.1 DUF3757 domain-containing protein -
HKK55_RS03245 712347..713459 - 1113 WP_169353340.1 enoyl-CoA hydratase/isomerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(5-92)

Antitoxin

Uncharacterized protein HI1420

(4-92)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10204.83 Da        Isoelectric Point: 11.2779

>T155649 WP_169353334.1 NZ_CP052859:c708481-708200 [Pseudomonas sp. ADAK18]
VNYLIQQTQTFITWHTAIRDLRAKIAIARRIDRASIGNLGDIKTVGGGVSEMRVDVGVGYRVRGRTVIVLLAGGDKSSQD
ADIRRAKKLAKEV

Download         Length: 282 bp

>T155649 NZ_CP068810:2355587-2355690 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10644.20 Da        Isoelectric Point: 5.6642

>AT155649 WP_169353333.1 NZ_CP052859:c708197-707898 [Pseudomonas sp. ADAK18]
MSQTLTTFDMVALLDSDEAISEYLSQVLADGDNEEFLRAVGYVAKARGMAKIATGTGMGRESLYKAFAPGAKPRFETVLK
VLHSLGIDLLAQPGHVANR

Download         Length: 300 bp

>AT155649 NZ_CP068810:c2355728-2355457 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGCCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References