155642

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 5951171..5951784 Replicon chromosome
Accession NZ_CP052857
Organism Pseudomonas sp. ADAK21

Toxin (Protein)


Gene name hicA Uniprot ID A0A1S1UTY1
Locus tag HKK57_RS26590 Protein ID WP_029293161.1
Coordinates 5951171..5951422 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1S1UV42
Locus tag HKK57_RS26595 Protein ID WP_070995596.1
Coordinates 5951419..5951784 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKK57_RS26590 5951171..5951422 + 252 WP_029293161.1 type II toxin-antitoxin system HicA family toxin Toxin
HKK57_RS26595 5951419..5951784 + 366 WP_070995596.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HKK57_RS26600 5951786..5952958 - 1173 WP_169391145.1 MFS transporter -
HKK57_RS26605 5953101..5953685 + 585 WP_070995594.1 TetR/AcrR family transcriptional regulator -
HKK57_RS26610 5953766..5955289 - 1524 WP_169391146.1 multidrug efflux MFS transporter -
HKK57_RS26615 5955279..5956430 - 1152 WP_092235435.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9408.00 Da        Isoelectric Point: 9.6951

>T155642 WP_029293161.1 NZ_CP052857:5951171-5951422 [Pseudomonas sp. ADAK21]
VSKNEKLLAKLLNLQMAFTWPELVTLLGWLGYRQIEGAGSRVKFDIGDPSAMITLHKPHPGNELKHYIRRQIIEQLESGG
LLQ

Download         Length: 252 bp

>T155642 NZ_CP068810:c629627-629163 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAGCCCATTGA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13246.06 Da        Isoelectric Point: 6.9569

>AT155642 WP_070995596.1 NZ_CP052857:5951419-5951784 [Pseudomonas sp. ADAK21]
MSNQLKYKGYIGSIEASVEDNCLFGKLLFIRALVSYEGQTVAQLEAAFREAVEDYLTTCQTLGQAPEKPCKGSFNVRVGH
DLHLAAALAATQKKVTLNDLTRQALNEFLRHHAADSHPALG

Download         Length: 366 bp

>AT155642 NZ_CP068810:c629962-629627 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACACTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S1UTY1

Antitoxin

Source ID Structure
AlphaFold DB A0A1S1UV42

References