Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 391938..392554 Replicon chromosome
Accession NZ_CP052857
Organism Pseudomonas sp. ADAK21

Toxin (Protein)


Gene name hicA Uniprot ID A0A1S1UW78
Locus tag HKK57_RS01810 Protein ID WP_029292612.1
Coordinates 392366..392554 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7Y1DEL1
Locus tag HKK57_RS01805 Protein ID WP_029292614.1
Coordinates 391938..392342 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKK57_RS01785 387525..388400 + 876 WP_169389699.1 urea transporter -
HKK57_RS01790 388432..389256 + 825 WP_029292622.1 ion transporter -
HKK57_RS01795 389350..390354 + 1005 WP_029292620.1 sulfate ABC transporter substrate-binding protein -
HKK57_RS01800 390596..391792 + 1197 WP_178121969.1 MFS transporter -
HKK57_RS01805 391938..392342 - 405 WP_029292614.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HKK57_RS01810 392366..392554 - 189 WP_029292612.1 type II toxin-antitoxin system HicA family toxin Toxin
HKK57_RS01815 392676..393425 - 750 WP_169389700.1 phosphonate metabolism protein PhnP -
HKK57_RS01820 393416..393982 - 567 WP_169391168.1 phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN -
HKK57_RS01825 394330..394725 - 396 WP_029292605.1 hypothetical protein -
HKK57_RS01830 394742..395935 - 1194 WP_029292603.1 c-type cytochrome biogenesis protein CcmI -
HKK57_RS01835 395928..396401 - 474 WP_029292601.1 cytochrome c-type biogenesis protein CcmH -
HKK57_RS01840 396398..396934 - 537 WP_029292599.1 DsbE family thiol:disulfide interchange protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7120.29 Da        Isoelectric Point: 11.5133

>T155637 WP_029292612.1 NZ_CP052857:c392554-392366 [Pseudomonas sp. ADAK21]
VQSRLLIKELQAAGWVLDRVTGSHHIFTHRYNPYTIPVPHPKKDLPLGTVRSIRQRAGLFSF

Download         Length: 189 bp

>T155637 NZ_CP068809:c4872305-4871994 [Escherichia coli]
ATCCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14742.74 Da        Isoelectric Point: 4.6115

>AT155637 WP_029292614.1 NZ_CP052857:c392342-391938 [Pseudomonas sp. ADAK21]
MQYPICIEWGDDFTATGIQIPDIPGAVTAGDSFEEAYNAAVEVAHIMLQEMASEGRAIPMPTSVAAHHGNEEYAGMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHKVKSRSSFLADAALEKLVRS

Download         Length: 405 bp

>AT155637 NZ_CP068809:c4871993-4871703 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S1UW78

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y1DEL1

References