Detailed information of TA system TA155634

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1682090..1682612
• Replicon: chromosome
• Accession: NZ_CP052855
• Organism: Xylella fastidiosa subsp. multiplex strain Fillmore

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HKJ31_RS07695
• Protein ID: WP_004085905.1
• Coordinates: 1682325..1682612 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A060HDF9
• Locus tag: HKJ31_RS07690
• Protein ID: WP_004085758.1
• Coordinates: 1682090..1682332 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HKJ31_RS07660	1677500..1677682	+	183	WP_027700467.1	hypothetical protein	-
HKJ31_RS07665	1677966..1678892	-	927	WP_004085766.1	Grx4 family monothiol glutaredoxin	-
HKJ31_RS07670	1678958..1679734	+	777	WP_027700469.1	polysaccharide deacetylase family protein	-
HKJ31_RS07675	1680378..1680569	-	192	WP_021358405.1	hypothetical protein	-
HKJ31_RS07680	1680987..1681406	-	420	WP_004085763.1	putative toxin-antitoxin system toxin component, PIN family	-
HKJ31_RS07685	1681406..1681645	-	240	WP_004085761.1	ribbon-helix-helix domain-containing protein	-
HKJ31_RS07690	1682090..1682332	+	243	WP_004085758.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
HKJ31_RS07695	1682325..1682612	+	288	WP_004085905.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HKJ31_RS07700	1682700..1683266	+	567	WP_004085755.1	recombinase family protein	-
HKJ31_RS07705	1683319..1684515	-	1197	WP_004083925.1	transposase	-
HKJ31_RS07710	1684509..1685135	-	627	WP_038230952.1	IS607 family transposase	-
HKJ31_RS07715	1685365..1686639	-	1275	WP_012337985.1	pyridoxal phosphate-dependent aminotransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1680378..1701880	21502
	-	flank	IS/Tn	-	-	1682700..1683266	566

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-90)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11159.64 Da
• Isoelectric Point: 5.9570

>T155634 WP_004085905.1 NZ_CP052855:1682325-1682612 [Xylella fastidiosa subsp. multiplex]
MAKSYRLTPLAEADLEEIWFYTFRHWSIEQADSYHRSLVAVFEGLAAGTKQGCPSVLPDFNKYLCGSHVVYFMDYADHLD
IIRILHQRQDTERYL

Nucleotide

• Length: 288 bp

>T155634 NZ_CP068809:4340627-4340968 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACTGCGGTAGATGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTCGCCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8774.77 Da
• Isoelectric Point: 6.9881

>AT155634 WP_004085758.1 NZ_CP052855:1682090-1682332 [Xylella fastidiosa subsp. multiplex]
MSRNTSVALGPHFTSFIDAQVQGGRYGTASDVVRAGLRLLEEHETKVKALQDALNVGHQSGEPRPFDSEVFLSRMHTQHG

Nucleotide

• Length: 243 bp

>AT155634 NZ_CP068809:c4340632-4340556 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin

• AlphaFold DB: A0A060HDF9