Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1405424..1406035 Replicon chromosome
Accession NZ_CP052855
Organism Xylella fastidiosa subsp. multiplex strain Fillmore

Toxin (Protein)


Gene name relE Uniprot ID A0A060HHU8
Locus tag HKJ31_RS06390 Protein ID WP_024749166.1
Coordinates 1405424..1405723 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q879U0
Locus tag HKJ31_RS06395 Protein ID WP_004085003.1
Coordinates 1405727..1406035 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKJ31_RS06355 1400636..1401196 - 561 WP_004084996.1 DUF2612 domain-containing protein -
HKJ31_RS06360 1401193..1402338 - 1146 WP_169710358.1 baseplate J/gp47 family protein -
HKJ31_RS06365 1402431..1402784 - 354 WP_020851652.1 hypothetical protein -
HKJ31_RS06370 1402781..1403422 - 642 WP_012382583.1 hypothetical protein -
HKJ31_RS06375 1403419..1404249 - 831 WP_004085594.1 hypothetical protein -
HKJ31_RS06380 1404246..1404563 - 318 WP_169710077.1 hypothetical protein -
HKJ31_RS06385 1404563..1405333 - 771 WP_169710359.1 hypothetical protein -
HKJ31_RS06390 1405424..1405723 + 300 WP_024749166.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HKJ31_RS06395 1405727..1406035 + 309 WP_004085003.1 putative addiction module antidote protein Antitoxin
HKJ31_RS06400 1406109..1406324 - 216 Protein_1241 hypothetical protein -
HKJ31_RS06405 1406321..1406713 - 393 Protein_1242 hypothetical protein -
HKJ31_RS06410 1406710..1407540 - 831 WP_004085594.1 hypothetical protein -
HKJ31_RS06415 1407537..1407854 - 318 WP_169710077.1 hypothetical protein -
HKJ31_RS06420 1407854..1408624 - 771 WP_169710321.1 hypothetical protein -
HKJ31_RS06425 1408672..1408962 + 291 WP_004087089.1 hypothetical protein -
HKJ31_RS06430 1408946..1409212 + 267 WP_004087087.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1399478..1425372 25894


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-98)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11364.14 Da        Isoelectric Point: 10.3861

>T155633 WP_024749166.1 NZ_CP052855:1405424-1405723 [Xylella fastidiosa subsp. multiplex]
MTYTVKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Download         Length: 300 bp

>T155633 NZ_CP068809:4215438-4215590 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11060.61 Da        Isoelectric Point: 4.6535

>AT155633 WP_004085003.1 NZ_CP052855:1405727-1406035 [Xylella fastidiosa subsp. multiplex]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Download         Length: 309 bp

>AT155633 NZ_CP068809:c4215389-4215332 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HHU8

Antitoxin

Source ID Structure
AlphaFold DB A0A060HCD4

References