Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1504151..1504762 Replicon chromosome
Accession NZ_CP052854
Organism Xylella fastidiosa subsp. multiplex strain LM10

Toxin (Protein)


Gene name relE Uniprot ID A0A060HHU8
Locus tag HKJ32_RS06955 Protein ID WP_024749166.1
Coordinates 1504151..1504450 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q879U0
Locus tag HKJ32_RS06960 Protein ID WP_004085003.1
Coordinates 1504454..1504762 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKJ32_RS06920 1499364..1499924 - 561 WP_004084996.1 DUF2612 domain-containing protein -
HKJ32_RS06925 1499921..1501068 - 1148 Protein_1352 baseplate J/gp47 family protein -
HKJ32_RS06930 1501161..1501514 - 354 WP_169709941.1 hypothetical protein -
HKJ32_RS06935 1501511..1502152 - 642 WP_004084999.1 hypothetical protein -
HKJ32_RS06940 1502149..1502979 - 831 WP_169709942.1 hypothetical protein -
HKJ32_RS06945 1502976..1503293 - 318 WP_012382585.1 hypothetical protein -
HKJ32_RS06950 1503293..1504063 - 771 WP_169710078.1 hypothetical protein -
HKJ32_RS06955 1504151..1504450 + 300 WP_024749166.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HKJ32_RS06960 1504454..1504762 + 309 WP_004085003.1 putative addiction module antidote protein Antitoxin
HKJ32_RS06965 1504836..1506725 - 1890 WP_169710183.1 hypothetical protein -
HKJ32_RS06970 1506873..1507295 - 423 WP_169710028.1 hypothetical protein -
HKJ32_RS06975 1507292..1507729 - 438 WP_004085006.1 DUF3277 family protein -
HKJ32_RS06980 1507739..1509235 - 1497 WP_128283792.1 DUF3383 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1498203..1566548 68345


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-98)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11364.14 Da        Isoelectric Point: 10.3861

>T155625 WP_024749166.1 NZ_CP052854:1504151-1504450 [Xylella fastidiosa subsp. multiplex]
MTYTVKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Download         Length: 300 bp

>T155625 NZ_CP068809:2788269-2788376 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11060.61 Da        Isoelectric Point: 4.6535

>AT155625 WP_004085003.1 NZ_CP052854:1504454-1504762 [Xylella fastidiosa subsp. multiplex]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Download         Length: 309 bp

>AT155625 NZ_CP068809:c2788216-2788155 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HHU8

Antitoxin

Source ID Structure
AlphaFold DB A0A060HCD4

References