Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 681208..681819 Replicon chromosome
Accession NZ_CP052853
Organism Xylella fastidiosa subsp. multiplex strain RH1

Toxin (Protein)


Gene name relE Uniprot ID A0A060HHU8
Locus tag HKJ33_RS02990 Protein ID WP_024749166.1
Coordinates 681208..681507 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q879U0
Locus tag HKJ33_RS02995 Protein ID WP_004085003.1
Coordinates 681511..681819 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKJ33_RS02950 676322..677467 - 1146 WP_169709940.1 baseplate J/gp47 family protein -
HKJ33_RS02955 677570..677866 + 297 WP_004085590.1 type II toxin-antitoxin system RelE/ParE family toxin -
HKJ33_RS02960 677869..678162 + 294 WP_004085592.1 putative addiction module antidote protein -
HKJ33_RS02965 678218..678571 - 354 WP_169709941.1 hypothetical protein -
HKJ33_RS02970 678568..679209 - 642 WP_004084999.1 hypothetical protein -
HKJ33_RS02975 679206..680036 - 831 WP_169709942.1 hypothetical protein -
HKJ33_RS02980 680033..680350 - 318 WP_012382585.1 hypothetical protein -
HKJ33_RS02985 680350..681120 - 771 WP_169709943.1 hypothetical protein -
HKJ33_RS02990 681208..681507 + 300 WP_024749166.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HKJ33_RS02995 681511..681819 + 309 WP_004085003.1 putative addiction module antidote protein Antitoxin
HKJ33_RS03000 681893..683782 - 1890 WP_169709944.1 hypothetical protein -
HKJ33_RS03005 683930..684351 - 422 Protein_575 hypothetical protein -
HKJ33_RS03010 684348..684785 - 438 WP_004085006.1 DUF3277 family protein -
HKJ33_RS03015 684795..686291 - 1497 WP_128283792.1 DUF3383 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 674598..718839 44241


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-98)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11364.14 Da        Isoelectric Point: 10.3861

>T155614 WP_024749166.1 NZ_CP052853:681208-681507 [Xylella fastidiosa subsp. multiplex]
MTYTVKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Download         Length: 300 bp

>T155614 NZ_CP068809:188778-188885 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11060.61 Da        Isoelectric Point: 4.6535

>AT155614 WP_004085003.1 NZ_CP052853:681511-681819 [Xylella fastidiosa subsp. multiplex]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Download         Length: 309 bp

>AT155614 NZ_CP068809:c188729-188663 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATATTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HHU8

Antitoxin

Source ID Structure
AlphaFold DB A0A060HCD4

References