Detailed information of TA system TA155611

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 502028..502559
• Replicon: chromosome
• Accession: NZ_CP052853
• Organism: Xylella fastidiosa subsp. multiplex strain RH1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HKJ33_RS02125
• Protein ID: WP_004086966.1
• Coordinates: 502278..502559 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: A0A060H9I0
• Locus tag: HKJ33_RS02120
• Protein ID: WP_004086967.1
• Coordinates: 502028..502291 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HKJ33_RS02095	497255..498433	-	1179	WP_154436952.1	phage tail sheath family protein	-
HKJ33_RS02100	498497..500089	-	1593	WP_169709923.1	tail fiber domain-containing protein	-
HKJ33_RS02105	500097..500654	-	558	WP_004086970.1	phage tail protein I	-
HKJ33_RS02110	500647..501540	-	894	WP_004085178.1	baseplate J/gp47 family protein	-
HKJ33_RS02115	501540..501878	-	339	WP_004088650.1	GPW/gp25 family protein	-
HKJ33_RS02120	502028..502291	+	264	WP_004086967.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HKJ33_RS02125	502278..502559	+	282	WP_004086966.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HKJ33_RS02130	502596..503183	-	588	WP_128283746.1	phage baseplate assembly protein V	-
HKJ33_RS02135	503180..503722	-	543	WP_154436958.1	hypothetical protein	-
HKJ33_RS02140	503698..504219	-	522	WP_154436960.1	hypothetical protein	-
HKJ33_RS02145	504216..504539	-	324	WP_169709908.1	hypothetical protein	-
HKJ33_RS02150	504539..504799	-	261	WP_012337650.1	hypothetical protein	-
HKJ33_RS02155	504817..506691	-	1875	WP_154436964.1	phage major capsid protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	474721..523204	48483

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-70)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10848.31 Da
• Isoelectric Point: 7.5505

>T155611 WP_004086966.1 NZ_CP052853:502278-502559 [Xylella fastidiosa subsp. multiplex]
MRRISQTGQFKRDYKREAKGQHRATLDEELIHVLEALACDHPLEPRHHDHALTGGWKDHRDCHIKPDLVLIYRKPDNETL
QLVRIGSHSELGL

Nucleotide

• Length: 282 bp

>T155611 NZ_CP068808:4784695-4785072 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAATATTATCCTGGGTAAGCACCCGGAGGTGAAACAATGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9525.98 Da
• Isoelectric Point: 5.6033

>AT155611 WP_004086967.1 NZ_CP052853:502028-502291 [Xylella fastidiosa subsp. multiplex]
MSANAVVRARVDTHIKEEASTVLATMGLSVSDAFRMMLTRIAREKALPFEPLVPNETTIAAMREARAGHLKSFDSIEALM
ADLHAED

Nucleotide

• Length: 264 bp

>AT155611 NZ_CP068808:4784238-4784606 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGTACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A060H9I0