Detailed information of TA system TA155609

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3381730..3382366
• Replicon: chromosome
• Accession: NZ_CP052851
• Organism: Bordetella parapertussis strain J677

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q7W5Z1
• Locus tag: FYB56_RS15900
• Protein ID: WP_010928914.1
• Coordinates: 3381730..3381912 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q7W5Z0
• Locus tag: FYB56_RS15905
• Protein ID: WP_010928915.1
• Coordinates: 3381974..3382366 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB56_RS15880	3377304..3377981	+	678	WP_010928910.1	HAD-IA family hydrolase	-
FYB56_RS15885	3378199..3379386	+	1188	WP_010928911.1	MFS transporter	-
FYB56_RS15895	3379961..3381181	+	1221	WP_010928912.1	ISL3-like element IS1001 family transposase	-
FYB56_RS15900	3381730..3381912	+	183	WP_010928914.1	type II toxin-antitoxin system HicA family toxin	Toxin
FYB56_RS15905	3381974..3382366	+	393	WP_010928915.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FYB56_RS15910	3382639..3383548	-	910	Protein_3140	LysR family transcriptional regulator	-
FYB56_RS15915	3383673..3384647	+	975	WP_010928916.1	tripartite tricarboxylate transporter substrate binding protein	-
FYB56_RS15920	3384682..3385041	+	360	WP_010928917.1	hypothetical protein	-
FYB56_RS15925	3385108..3386280	+	1173	WP_010928918.1	thiolase domain-containing protein	-
FYB56_RS15930	3386284..3386710	+	427	Protein_3144	OB-fold domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3379961..3381181	1220

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6572.69 Da
• Isoelectric Point: 10.9062

>T155609 WP_010928914.1 NZ_CP052851:3381730-3381912 [Bordetella parapertussis]
MDGKELIKQLERSGWTLRSVKGSHHVFAHPDRPGHISVPHPKKDLGIGLLNSILKAAGLK

Nucleotide

• Length: 183 bp

>T155609 NZ_CP068808:c4605755-4605465 [Escherichia coli]
ATGAACTATGAGCTGGCGTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGAGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTGCGGGATTTACCGGACTGCTACAAAATTA
AGCTGCGCACACAGGGATATCGCCTGGTTTATCAGGTTAACGATAAAGAGTTGCTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTATGAAGACGCGACTAAACGGCTGGATGAGTGA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 14058.82 Da
• Isoelectric Point: 4.2876

>AT155609 WP_010928915.1 NZ_CP052851:3381974-3382366 [Bordetella parapertussis]
VKYPIAIEPGSDTRAWGVVVPDLPGCFSAADEGIDQAIENAKEAIELWIETAIDSGAPIPAATNIANHQANPEFANWIWA
IADVDPAVLDETVERVNITIPRRILKRLDDRARAAGESRSSYIAHLAMTA

Nucleotide

• Length: 393 bp

>AT155609 NZ_CP068808:c4605987-4605745 [Escherichia coli]
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATCACGCC
TACTGAAGCAGTGCGGCTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCAACCCACAAGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA

Structures

Toxin

• AlphaFold DB: Q7W5Z1

Antitoxin

• AlphaFold DB: Q7W5Z0