Detailed information of TA system TA155604

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3379678..3380314
• Replicon: chromosome
• Accession: NZ_CP052850
• Organism: Bordetella parapertussis strain J778

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q7W5Z1
• Locus tag: FYB61_RS15895
• Protein ID: WP_010928914.1
• Coordinates: 3379678..3379860 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q7W5Z0
• Locus tag: FYB61_RS15900
• Protein ID: WP_010928915.1
• Coordinates: 3379922..3380314 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB61_RS15875	3375252..3375929	+	678	WP_010928910.1	HAD-IA family hydrolase	-
FYB61_RS15880	3376147..3377334	+	1188	WP_010928911.1	MFS transporter	-
FYB61_RS15890	3377909..3379129	+	1221	WP_010928912.1	ISL3-like element IS1001 family transposase	-
FYB61_RS15895	3379678..3379860	+	183	WP_010928914.1	type II toxin-antitoxin system HicA family toxin	Toxin
FYB61_RS15900	3379922..3380314	+	393	WP_010928915.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FYB61_RS15905	3380587..3381496	-	910	Protein_3139	LysR family transcriptional regulator	-
FYB61_RS15910	3381621..3382595	+	975	WP_010928916.1	tripartite tricarboxylate transporter substrate binding protein	-
FYB61_RS15915	3382630..3382989	+	360	WP_010928917.1	hypothetical protein	-
FYB61_RS15920	3383056..3384228	+	1173	WP_010928918.1	thiolase domain-containing protein	-
FYB61_RS15925	3384232..3384658	+	427	Protein_3143	OB-fold domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3377909..3379129	1220

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6572.69 Da
• Isoelectric Point: 10.9062

>T155604 WP_010928914.1 NZ_CP052850:3379678-3379860 [Bordetella parapertussis]
MDGKELIKQLERSGWTLRSVKGSHHVFAHPDRPGHISVPHPKKDLGIGLLNSILKAAGLK

Nucleotide

• Length: 183 bp

>T155604 NZ_CP068808:3872036-3872254 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 14058.82 Da
• Isoelectric Point: 4.2876

>AT155604 WP_010928915.1 NZ_CP052850:3379922-3380314 [Bordetella parapertussis]
VKYPIAIEPGSDTRAWGVVVPDLPGCFSAADEGIDQAIENAKEAIELWIETAIDSGAPIPAATNIANHQANPEFANWIWA
IADVDPAVLDETVERVNITIPRRILKRLDDRARAAGESRSSYIAHLAMTA

Nucleotide

• Length: 393 bp

>AT155604 NZ_CP068808:3871636-3872010 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: Q7W5Z1

Antitoxin

• AlphaFold DB: Q7W5Z0