Detailed information of TA system TA155603

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 3160586..3161247
• Replicon: chromosome
• Accession: NZ_CP052850
• Organism: Bordetella parapertussis strain J778

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q7WAH5
• Locus tag: FYB61_RS14900
• Protein ID: WP_003812073.1
• Coordinates: 3160822..3161247 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FYB61_RS14895
• Protein ID: WP_003812071.1
• Coordinates: 3160586..3160825 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB61_RS14860	3155621..3156424	-	804	WP_003812055.1	bacteriocin family protein	-
FYB61_RS14865	3156421..3157467	-	1047	WP_010928022.1	Dyp-type peroxidase	-
FYB61_RS14870	3157545..3158105	-	561	WP_010928021.1	DUF488 domain-containing protein	-
FYB61_RS14875	3158102..3158335	-	234	WP_033447224.1	DUF2945 domain-containing protein	-
FYB61_RS14880	3158416..3158928	-	513	WP_003812062.1	redoxin domain-containing protein	-
FYB61_RS14885	3158987..3159532	-	546	WP_010928020.1	peroxidase-related enzyme	-
FYB61_RS14890	3159670..3160512	+	843	WP_010928019.1	AraC family transcriptional regulator	-
FYB61_RS14895	3160586..3160825	+	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
FYB61_RS14900	3160822..3161247	+	426	WP_003812073.1	PIN domain-containing protein	Toxin
FYB61_RS14905	3161357..3161821	+	465	WP_003812075.1	MarR family transcriptional regulator	-
FYB61_RS14910	3161919..3163424	-	1506	WP_010928018.1	tripartite tricarboxylate transporter permease	-
FYB61_RS14915	3163923..3164435	+	513	WP_010928017.1	hypothetical protein	-
FYB61_RS14920	3164456..3165433	-	978	WP_003812083.1	tripartite tricarboxylate transporter substrate binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14811.22 Da
• Isoelectric Point: 6.3704

>T155603 WP_003812073.1 NZ_CP052850:3160822-3161247 [Bordetella parapertussis]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Nucleotide

• Length: 426 bp

>T155603 NZ_CP068808:3418588-3418974 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT155603 WP_003812071.1 NZ_CP052850:3160586-3160825 [Bordetella parapertussis]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT155603 NZ_CP068808:3418964-3419293 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Structures

Toxin

• AlphaFold DB: Q7WAH5