Detailed information of TA system TA155599

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 4268525..4269098
• Replicon: chromosome
• Accession: NZ_CP052848
• Organism: Bordetella hinzii strain 1G1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: W5IUR0
• Locus tag: HHA21_RS20250
• Protein ID: WP_009618209.1
• Coordinates: 4268811..4269098 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HHA21_RS20245
• Protein ID: WP_044061215.1
• Coordinates: 4268525..4268824 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHA21_RS20215 (HHA21_20220)	4263610..4263828	+	219	WP_009461157.1	AlpA family transcriptional regulator	-
HHA21_RS20220 (HHA21_20225)	4263870..4264736	+	867	WP_215600172.1	ParA family protein	-
HHA21_RS20225 (HHA21_20230)	4264720..4264968	+	249	WP_032972660.1	hypothetical protein	-
HHA21_RS20230 (HHA21_20235)	4264961..4266619	+	1659	WP_215600173.1	ParB family protein	-
HHA21_RS20235 (HHA21_20240)	4266637..4267197	+	561	WP_027350499.1	DUF2857 domain-containing protein	-
HHA21_RS20240 (HHA21_20245)	4267200..4268393	+	1194	WP_027350500.1	STY4528 family pathogenicity island replication protein	-
HHA21_RS20245 (HHA21_20250)	4268525..4268824	+	300	WP_044061215.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HHA21_RS20250 (HHA21_20255)	4268811..4269098	+	288	WP_009618209.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HHA21_RS20255 (HHA21_20260)	4269127..4269318	+	192	WP_027350501.1	hypothetical protein	-
HHA21_RS20260 (HHA21_20265)	4269442..4270221	+	780	WP_215600174.1	TIGR03761 family integrating conjugative element protein	-
HHA21_RS20265 (HHA21_20270)	4270218..4270766	+	549	WP_215600175.1	DUF3158 family protein	-
HHA21_RS20270 (HHA21_20275)	4270763..4271146	+	384	WP_027350504.1	single-stranded DNA-binding protein	-
HHA21_RS20275 (HHA21_20280)	4271428..4273443	+	2016	WP_215600176.1	DNA topoisomerase III	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4255111..4269098	13987

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-54)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10854.46 Da
• Isoelectric Point: 8.4628

>T155599 WP_009618209.1 NZ_CP052848:4268811-4269098 [Bordetella hinzii]
VRVLEWREAARADLLAIVDYISDDNPDAAQRLKDDIEAKAAKLPERPKLYRPGRVAGTREMVVRANYVVVYMEDTRAVSI
LRVLHAAQQWPPARE

Nucleotide

• Length: 288 bp

>T155599 NZ_CP068808:c2736200-2736024 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGCGTCACCCCAGCGAAGAGATTAAAGAACCATTGCGTAAAGCCATTCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10903.59 Da
• Isoelectric Point: 10.2615

>AT155599 WP_044061215.1 NZ_CP052848:4268525-4268824 [Bordetella hinzii]
MAAQTSMLHIRVDDKLKADAAEKLAGVGLTVSDAVRILLTRVVKEGALPAGLTADPEAYDAWFRAKVQEALADTRPPVRH
RQVMDEAQALIDRKRRART

Nucleotide

• Length: 300 bp

>AT155599 NZ_CP068808:c2735978-2735562 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATCAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAAAT
TACTCGCTTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Toxin

• AlphaFold DB: A0A5R9QF16