Detailed information of TA system TA155598

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2734721..2735277
• Replicon: chromosome
• Accession: NZ_CP052848
• Organism: Bordetella hinzii strain 1G1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HHA21_RS12695
• Protein ID: WP_032978872.1
• Coordinates: 2734721..2735011 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HHA21_RS12700
• Protein ID: WP_032957511.1
• Coordinates: 2734999..2735277 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHA21_RS12680 (HHA21_12675)	2732982..2733764	-	783	WP_032978897.1	DUF1837 domain-containing protein	-
HHA21_RS23330 (HHA21_12680)	2733990..2734448	-	459	WP_080700866.1	XRE family transcriptional regulator	-
HHA21_RS12690 (HHA21_12685)	2734460..2734720	-	261	WP_032978875.1	hypothetical protein	-
HHA21_RS12695 (HHA21_12690)	2734721..2735011	-	291	WP_032978872.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HHA21_RS12700 (HHA21_12695)	2734999..2735277	-	279	WP_032957511.1	CopG family ribbon-helix-helix protein	Antitoxin
HHA21_RS12705 (HHA21_12700)	2735482..2735733	+	252	WP_032978869.1	hypothetical protein	-
HHA21_RS12710 (HHA21_12705)	2735856..2736587	+	732	WP_032978894.1	recombinase family protein	-
HHA21_RS12715 (HHA21_12710)	2736584..2736754	+	171	WP_155271649.1	hypothetical protein	-
HHA21_RS12720 (HHA21_12715)	2736786..2737121	-	336	Protein_2521	AAA family ATPase	-
HHA21_RS12725 (HHA21_12720)	2737124..2737261	-	138	Protein_2522	AlpA family phage regulatory protein	-
HHA21_RS12730 (HHA21_12725)	2737382..2737624	-	243	Protein_2523	tyrosine-type recombinase/integrase	-
HHA21_RS12740 (HHA21_12735)	2738949..2739917	-	969	Protein_2525	integrase arm-type DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2726586..2739917	13331

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10900.56 Da
• Isoelectric Point: 9.5041

>T155598 WP_032978872.1 NZ_CP052848:c2735011-2734721 [Bordetella hinzii]
VPRLIWTPPAVADVQRLYRFLAPKDADAAQRAVKAIRAGVKILAHQPRIGRPVEDMEPEFREWLIDFGNSGYVALYRFDG
ENIAILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T155598 NZ_CP068808:2627798-2629120 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAATGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAACCGTTATGCCAGACCGTTATCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
TGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTGCCGGACGCAGAAATCATTAAAGCGGGGAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTGTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTATTGGGTGGCGCAGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGGTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTTCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGGCCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10801.20 Da
• Isoelectric Point: 6.0964

>AT155598 WP_032957511.1 NZ_CP052848:c2735277-2734999 [Bordetella hinzii]
MARATSIKLDDELKGRVQHLAEARRRTSHWIMREAIAQYVEREEKREAFKQDALRAWEEYQRTGLHLTLEEADAWLAKLE
AGEDAELPKCHV

Nucleotide

• Length: 279 bp

>AT155598 NZ_CP068808:2627532-2627798 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGTCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TGACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA