Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 2734721..2735277 Replicon chromosome
Accession NZ_CP052848
Organism Bordetella hinzii strain 1G1

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag HHA21_RS12695 Protein ID WP_032978872.1
Coordinates 2734721..2735011 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HHA21_RS12700 Protein ID WP_032957511.1
Coordinates 2734999..2735277 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHA21_RS12680 (HHA21_12675) 2732982..2733764 - 783 WP_032978897.1 DUF1837 domain-containing protein -
HHA21_RS23330 (HHA21_12680) 2733990..2734448 - 459 WP_080700866.1 XRE family transcriptional regulator -
HHA21_RS12690 (HHA21_12685) 2734460..2734720 - 261 WP_032978875.1 hypothetical protein -
HHA21_RS12695 (HHA21_12690) 2734721..2735011 - 291 WP_032978872.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HHA21_RS12700 (HHA21_12695) 2734999..2735277 - 279 WP_032957511.1 CopG family ribbon-helix-helix protein Antitoxin
HHA21_RS12705 (HHA21_12700) 2735482..2735733 + 252 WP_032978869.1 hypothetical protein -
HHA21_RS12710 (HHA21_12705) 2735856..2736587 + 732 WP_032978894.1 recombinase family protein -
HHA21_RS12715 (HHA21_12710) 2736584..2736754 + 171 WP_155271649.1 hypothetical protein -
HHA21_RS12720 (HHA21_12715) 2736786..2737121 - 336 Protein_2521 AAA family ATPase -
HHA21_RS12725 (HHA21_12720) 2737124..2737261 - 138 Protein_2522 AlpA family phage regulatory protein -
HHA21_RS12730 (HHA21_12725) 2737382..2737624 - 243 Protein_2523 tyrosine-type recombinase/integrase -
HHA21_RS12740 (HHA21_12735) 2738949..2739917 - 969 Protein_2525 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2726586..2739917 13331


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10900.56 Da        Isoelectric Point: 9.5041

>T155598 WP_032978872.1 NZ_CP052848:c2735011-2734721 [Bordetella hinzii]
VPRLIWTPPAVADVQRLYRFLAPKDADAAQRAVKAIRAGVKILAHQPRIGRPVEDMEPEFREWLIDFGNSGYVALYRFDG
ENIAILAVRHQKEAGY

Download         Length: 291 bp

>T155598 NZ_CP068808:2627798-2629120 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAATGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAACCGTTATGCCAGACCGTTATCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
TGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTGCCGGACGCAGAAATCATTAAAGCGGGGAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTGTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTATTGGGTGGCGCAGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGGTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTTCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGGCCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10801.20 Da        Isoelectric Point: 6.0964

>AT155598 WP_032957511.1 NZ_CP052848:c2735277-2734999 [Bordetella hinzii]
MARATSIKLDDELKGRVQHLAEARRRTSHWIMREAIAQYVEREEKREAFKQDALRAWEEYQRTGLHLTLEEADAWLAKLE
AGEDAELPKCHV

Download         Length: 279 bp

>AT155598 NZ_CP068808:2627532-2627798 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGTCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TGACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References