Detailed information of TA system TA155596

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2788074..2788630
• Replicon: chromosome
• Accession: NZ_CP052847
• Organism: Bordetella hinzii strain 1G2

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HHA22_RS12940
• Protein ID: WP_032978872.1
• Coordinates: 2788074..2788364 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HHA22_RS12945
• Protein ID: WP_032957511.1
• Coordinates: 2788352..2788630 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHA22_RS12925 (HHA22_12920)	2786335..2787117	-	783	WP_032978897.1	DUF1837 domain-containing protein	-
HHA22_RS23585 (HHA22_12925)	2787343..2787801	-	459	WP_080700866.1	XRE family transcriptional regulator	-
HHA22_RS12935 (HHA22_12930)	2787813..2788073	-	261	WP_032978875.1	hypothetical protein	-
HHA22_RS12940 (HHA22_12935)	2788074..2788364	-	291	WP_032978872.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HHA22_RS12945 (HHA22_12940)	2788352..2788630	-	279	WP_032957511.1	CopG family ribbon-helix-helix protein	Antitoxin
HHA22_RS12950 (HHA22_12945)	2788835..2789086	+	252	WP_032978869.1	hypothetical protein	-
HHA22_RS12955 (HHA22_12950)	2789209..2789940	+	732	WP_032978894.1	recombinase family protein	-
HHA22_RS12960 (HHA22_12955)	2789937..2790107	+	171	WP_155271649.1	hypothetical protein	-
HHA22_RS12965 (HHA22_12960)	2790139..2790474	-	336	Protein_2572	AAA family ATPase	-
HHA22_RS12970 (HHA22_12965)	2790477..2790614	-	138	Protein_2573	AlpA family phage regulatory protein	-
HHA22_RS12975 (HHA22_12970)	2790735..2790977	-	243	Protein_2574	tyrosine-type recombinase/integrase	-
HHA22_RS12985 (HHA22_12980)	2792302..2793270	-	969	Protein_2576	integrase arm-type DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2776809..2800241	23432

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10900.56 Da
• Isoelectric Point: 9.5041

>T155596 WP_032978872.1 NZ_CP052847:c2788364-2788074 [Bordetella hinzii]
VPRLIWTPPAVADVQRLYRFLAPKDADAAQRAVKAIRAGVKILAHQPRIGRPVEDMEPEFREWLIDFGNSGYVALYRFDG
ENIAILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T155596 NZ_CP068808:c2024612-2024238 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10801.20 Da
• Isoelectric Point: 6.0964

>AT155596 WP_032957511.1 NZ_CP052847:c2788630-2788352 [Bordetella hinzii]
MARATSIKLDDELKGRVQHLAEARRRTSHWIMREAIAQYVEREEKREAFKQDALRAWEEYQRTGLHLTLEEADAWLAKLE
AGEDAELPKCHV

Nucleotide

• Length: 279 bp

>AT155596 NZ_CP068808:c2025069-2024701 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA