Detailed information of TA system TA155595

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 4322226..4322799
• Replicon: chromosome
• Accession: NZ_CP052846
• Organism: Bordetella hinzii strain 2B1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: W5IUR0
• Locus tag: HHA23_RS20495
• Protein ID: WP_009618209.1
• Coordinates: 4322512..4322799 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HHA23_RS20490
• Protein ID: WP_044061215.1
• Coordinates: 4322226..4322525 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHA23_RS20460 (HHA23_20460)	4317311..4317529	+	219	WP_009461157.1	AlpA family transcriptional regulator	-
HHA23_RS20465 (HHA23_20465)	4317571..4318437	+	867	WP_215600172.1	ParA family protein	-
HHA23_RS20470 (HHA23_20470)	4318421..4318669	+	249	WP_032972660.1	hypothetical protein	-
HHA23_RS20475 (HHA23_20475)	4318662..4320320	+	1659	WP_215600173.1	ParB family protein	-
HHA23_RS20480 (HHA23_20480)	4320338..4320898	+	561	WP_027350499.1	DUF2857 domain-containing protein	-
HHA23_RS20485 (HHA23_20485)	4320901..4322094	+	1194	WP_027350500.1	STY4528 family pathogenicity island replication protein	-
HHA23_RS20490 (HHA23_20490)	4322226..4322525	+	300	WP_044061215.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HHA23_RS20495 (HHA23_20495)	4322512..4322799	+	288	WP_009618209.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HHA23_RS20500 (HHA23_20500)	4322828..4323019	+	192	WP_027350501.1	hypothetical protein	-
HHA23_RS20505 (HHA23_20505)	4323143..4323922	+	780	WP_215600174.1	TIGR03761 family integrating conjugative element protein	-
HHA23_RS20510 (HHA23_20510)	4323919..4324467	+	549	WP_215600175.1	DUF3158 family protein	-
HHA23_RS20515 (HHA23_20515)	4324464..4324847	+	384	WP_027350504.1	single-stranded DNA-binding protein	-
HHA23_RS20520 (HHA23_20520)	4325129..4327144	+	2016	WP_215600176.1	DNA topoisomerase III	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4307461..4322799	15338

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-54)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10854.46 Da
• Isoelectric Point: 8.4628

>T155595 WP_009618209.1 NZ_CP052846:4322512-4322799 [Bordetella hinzii]
VRVLEWREAARADLLAIVDYISDDNPDAAQRLKDDIEAKAAKLPERPKLYRPGRVAGTREMVVRANYVVVYMEDTRAVSI
LRVLHAAQQWPPARE

Nucleotide

• Length: 288 bp

>T155595 NZ_CP068808:2012716-2012970 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10903.59 Da
• Isoelectric Point: 10.2615

>AT155595 WP_044061215.1 NZ_CP052846:4322226-4322525 [Bordetella hinzii]
MAAQTSMLHIRVDDKLKADAAEKLAGVGLTVSDAVRILLTRVVKEGALPAGLTADPEAYDAWFRAKVQEALADTRPPVRH
RQVMDEAQALIDRKRRART

Nucleotide

• Length: 300 bp

>AT155595 NZ_CP068808:2012468-2012719 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Structures

Toxin

• AlphaFold DB: A0A5R9QF16