Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 2788246..2788802 Replicon chromosome
Accession NZ_CP052846
Organism Bordetella hinzii strain 2B1

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag HHA23_RS12935 Protein ID WP_032978872.1
Coordinates 2788246..2788536 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HHA23_RS12940 Protein ID WP_032957511.1
Coordinates 2788524..2788802 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHA23_RS12920 (HHA23_12915) 2786507..2787289 - 783 WP_032978897.1 DUF1837 domain-containing protein -
HHA23_RS23575 (HHA23_12920) 2787515..2787973 - 459 WP_080700866.1 XRE family transcriptional regulator -
HHA23_RS12930 (HHA23_12925) 2787985..2788245 - 261 WP_032978875.1 hypothetical protein -
HHA23_RS12935 (HHA23_12930) 2788246..2788536 - 291 WP_032978872.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HHA23_RS12940 (HHA23_12935) 2788524..2788802 - 279 WP_032957511.1 CopG family ribbon-helix-helix protein Antitoxin
HHA23_RS12945 (HHA23_12940) 2789007..2789258 + 252 WP_032978869.1 hypothetical protein -
HHA23_RS12950 (HHA23_12945) 2789381..2790112 + 732 WP_032978894.1 recombinase family protein -
HHA23_RS12955 (HHA23_12950) 2790109..2790279 + 171 WP_155271649.1 hypothetical protein -
HHA23_RS12960 (HHA23_12955) 2790311..2790646 - 336 Protein_2569 AAA family ATPase -
HHA23_RS12965 (HHA23_12960) 2790649..2790786 - 138 Protein_2570 AlpA family phage regulatory protein -
HHA23_RS12970 (HHA23_12965) 2790907..2791149 - 243 Protein_2571 tyrosine-type recombinase/integrase -
HHA23_RS12980 (HHA23_12975) 2792474..2793442 - 969 Protein_2573 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2781112..2800413 19301


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10900.56 Da        Isoelectric Point: 9.5041

>T155594 WP_032978872.1 NZ_CP052846:c2788536-2788246 [Bordetella hinzii]
VPRLIWTPPAVADVQRLYRFLAPKDADAAQRAVKAIRAGVKILAHQPRIGRPVEDMEPEFREWLIDFGNSGYVALYRFDG
ENIAILAVRHQKEAGY

Download         Length: 291 bp

>T155594 NZ_CP068808:2012468-2012719 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10801.20 Da        Isoelectric Point: 6.0964

>AT155594 WP_032957511.1 NZ_CP052846:c2788802-2788524 [Bordetella hinzii]
MARATSIKLDDELKGRVQHLAEARRRTSHWIMREAIAQYVEREEKREAFKQDALRAWEEYQRTGLHLTLEEADAWLAKLE
AGEDAELPKCHV

Download         Length: 279 bp

>AT155594 NZ_CP068808:2012716-2012970 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References