Detailed information of TA system TA155594

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2788246..2788802
• Replicon: chromosome
• Accession: NZ_CP052846
• Organism: Bordetella hinzii strain 2B1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HHA23_RS12935
• Protein ID: WP_032978872.1
• Coordinates: 2788246..2788536 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HHA23_RS12940
• Protein ID: WP_032957511.1
• Coordinates: 2788524..2788802 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHA23_RS12920 (HHA23_12915)	2786507..2787289	-	783	WP_032978897.1	DUF1837 domain-containing protein	-
HHA23_RS23575 (HHA23_12920)	2787515..2787973	-	459	WP_080700866.1	XRE family transcriptional regulator	-
HHA23_RS12930 (HHA23_12925)	2787985..2788245	-	261	WP_032978875.1	hypothetical protein	-
HHA23_RS12935 (HHA23_12930)	2788246..2788536	-	291	WP_032978872.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HHA23_RS12940 (HHA23_12935)	2788524..2788802	-	279	WP_032957511.1	CopG family ribbon-helix-helix protein	Antitoxin
HHA23_RS12945 (HHA23_12940)	2789007..2789258	+	252	WP_032978869.1	hypothetical protein	-
HHA23_RS12950 (HHA23_12945)	2789381..2790112	+	732	WP_032978894.1	recombinase family protein	-
HHA23_RS12955 (HHA23_12950)	2790109..2790279	+	171	WP_155271649.1	hypothetical protein	-
HHA23_RS12960 (HHA23_12955)	2790311..2790646	-	336	Protein_2569	AAA family ATPase	-
HHA23_RS12965 (HHA23_12960)	2790649..2790786	-	138	Protein_2570	AlpA family phage regulatory protein	-
HHA23_RS12970 (HHA23_12965)	2790907..2791149	-	243	Protein_2571	tyrosine-type recombinase/integrase	-
HHA23_RS12980 (HHA23_12975)	2792474..2793442	-	969	Protein_2573	integrase arm-type DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2781112..2800413	19301

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10900.56 Da
• Isoelectric Point: 9.5041

>T155594 WP_032978872.1 NZ_CP052846:c2788536-2788246 [Bordetella hinzii]
VPRLIWTPPAVADVQRLYRFLAPKDADAAQRAVKAIRAGVKILAHQPRIGRPVEDMEPEFREWLIDFGNSGYVALYRFDG
ENIAILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T155594 NZ_CP068808:2012468-2012719 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10801.20 Da
• Isoelectric Point: 6.0964

>AT155594 WP_032957511.1 NZ_CP052846:c2788802-2788524 [Bordetella hinzii]
MARATSIKLDDELKGRVQHLAEARRRTSHWIMREAIAQYVEREEKREAFKQDALRAWEEYQRTGLHLTLEEADAWLAKLE
AGEDAELPKCHV

Nucleotide

• Length: 279 bp

>AT155594 NZ_CP068808:2012716-2012970 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA