Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 4322207..4322780 | Replicon | chromosome |
| Accession | NZ_CP052845 | ||
| Organism | Bordetella hinzii strain 2B3 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | W5IUR0 |
| Locus tag | HHA24_RS20495 | Protein ID | WP_009618209.1 |
| Coordinates | 4322493..4322780 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | HHA24_RS20490 | Protein ID | WP_044061215.1 |
| Coordinates | 4322207..4322506 (+) | Length | 100 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HHA24_RS20460 (HHA24_20460) | 4317292..4317510 | + | 219 | WP_009461157.1 | AlpA family transcriptional regulator | - |
| HHA24_RS20465 (HHA24_20465) | 4317552..4318418 | + | 867 | WP_215600172.1 | ParA family protein | - |
| HHA24_RS20470 (HHA24_20470) | 4318402..4318650 | + | 249 | WP_032972660.1 | hypothetical protein | - |
| HHA24_RS20475 (HHA24_20475) | 4318643..4320301 | + | 1659 | WP_215600173.1 | ParB family protein | - |
| HHA24_RS20480 (HHA24_20480) | 4320319..4320879 | + | 561 | WP_027350499.1 | DUF2857 domain-containing protein | - |
| HHA24_RS20485 (HHA24_20485) | 4320882..4322075 | + | 1194 | WP_027350500.1 | STY4528 family pathogenicity island replication protein | - |
| HHA24_RS20490 (HHA24_20490) | 4322207..4322506 | + | 300 | WP_044061215.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| HHA24_RS20495 (HHA24_20495) | 4322493..4322780 | + | 288 | WP_009618209.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HHA24_RS20500 (HHA24_20500) | 4322809..4323000 | + | 192 | WP_027350501.1 | hypothetical protein | - |
| HHA24_RS20505 (HHA24_20505) | 4323124..4323903 | + | 780 | WP_215600174.1 | TIGR03761 family integrating conjugative element protein | - |
| HHA24_RS20510 (HHA24_20510) | 4323900..4324448 | + | 549 | WP_215600175.1 | DUF3158 family protein | - |
| HHA24_RS20515 (HHA24_20515) | 4324445..4324828 | + | 384 | WP_027350504.1 | single-stranded DNA-binding protein | - |
| HHA24_RS20520 (HHA24_20520) | 4325110..4327125 | + | 2016 | WP_215600176.1 | DNA topoisomerase III | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4307442..4322780 | 15338 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10854.46 Da Isoelectric Point: 8.4628
>T155593 WP_009618209.1 NZ_CP052845:4322493-4322780 [Bordetella hinzii]
VRVLEWREAARADLLAIVDYISDDNPDAAQRLKDDIEAKAAKLPERPKLYRPGRVAGTREMVVRANYVVVYMEDTRAVSI
LRVLHAAQQWPPARE
VRVLEWREAARADLLAIVDYISDDNPDAAQRLKDDIEAKAAKLPERPKLYRPGRVAGTREMVVRANYVVVYMEDTRAVSI
LRVLHAAQQWPPARE
Download Length: 288 bp
>T155593 NZ_CP068808:1210581-1210892 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCTAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCTAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA
Antitoxin
Download Length: 100 a.a. Molecular weight: 10903.59 Da Isoelectric Point: 10.2615
>AT155593 WP_044061215.1 NZ_CP052845:4322207-4322506 [Bordetella hinzii]
MAAQTSMLHIRVDDKLKADAAEKLAGVGLTVSDAVRILLTRVVKEGALPAGLTADPEAYDAWFRAKVQEALADTRPPVRH
RQVMDEAQALIDRKRRART
MAAQTSMLHIRVDDKLKADAAEKLAGVGLTVSDAVRILLTRVVKEGALPAGLTADPEAYDAWFRAKVQEALADTRPPVRH
RQVMDEAQALIDRKRRART
Download Length: 300 bp
>AT155593 NZ_CP068808:1210889-1211308 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCCTTACTTCGTACGCTGATTGATCAACATAATTTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
TCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCATATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCCTTACTTCGTACGCTGATTGATCAACATAATTTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
TCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCATATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|