Detailed information of TA system TA155593

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 4322207..4322780
• Replicon: chromosome
• Accession: NZ_CP052845
• Organism: Bordetella hinzii strain 2B3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: W5IUR0
• Locus tag: HHA24_RS20495
• Protein ID: WP_009618209.1
• Coordinates: 4322493..4322780 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HHA24_RS20490
• Protein ID: WP_044061215.1
• Coordinates: 4322207..4322506 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHA24_RS20460 (HHA24_20460)	4317292..4317510	+	219	WP_009461157.1	AlpA family transcriptional regulator	-
HHA24_RS20465 (HHA24_20465)	4317552..4318418	+	867	WP_215600172.1	ParA family protein	-
HHA24_RS20470 (HHA24_20470)	4318402..4318650	+	249	WP_032972660.1	hypothetical protein	-
HHA24_RS20475 (HHA24_20475)	4318643..4320301	+	1659	WP_215600173.1	ParB family protein	-
HHA24_RS20480 (HHA24_20480)	4320319..4320879	+	561	WP_027350499.1	DUF2857 domain-containing protein	-
HHA24_RS20485 (HHA24_20485)	4320882..4322075	+	1194	WP_027350500.1	STY4528 family pathogenicity island replication protein	-
HHA24_RS20490 (HHA24_20490)	4322207..4322506	+	300	WP_044061215.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HHA24_RS20495 (HHA24_20495)	4322493..4322780	+	288	WP_009618209.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HHA24_RS20500 (HHA24_20500)	4322809..4323000	+	192	WP_027350501.1	hypothetical protein	-
HHA24_RS20505 (HHA24_20505)	4323124..4323903	+	780	WP_215600174.1	TIGR03761 family integrating conjugative element protein	-
HHA24_RS20510 (HHA24_20510)	4323900..4324448	+	549	WP_215600175.1	DUF3158 family protein	-
HHA24_RS20515 (HHA24_20515)	4324445..4324828	+	384	WP_027350504.1	single-stranded DNA-binding protein	-
HHA24_RS20520 (HHA24_20520)	4325110..4327125	+	2016	WP_215600176.1	DNA topoisomerase III	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4307442..4322780	15338

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-54)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10854.46 Da
• Isoelectric Point: 8.4628

>T155593 WP_009618209.1 NZ_CP052845:4322493-4322780 [Bordetella hinzii]
VRVLEWREAARADLLAIVDYISDDNPDAAQRLKDDIEAKAAKLPERPKLYRPGRVAGTREMVVRANYVVVYMEDTRAVSI
LRVLHAAQQWPPARE

Nucleotide

• Length: 288 bp

>T155593 NZ_CP068808:1210581-1210892 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCTAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10903.59 Da
• Isoelectric Point: 10.2615

>AT155593 WP_044061215.1 NZ_CP052845:4322207-4322506 [Bordetella hinzii]
MAAQTSMLHIRVDDKLKADAAEKLAGVGLTVSDAVRILLTRVVKEGALPAGLTADPEAYDAWFRAKVQEALADTRPPVRH
RQVMDEAQALIDRKRRART

Nucleotide

• Length: 300 bp

>AT155593 NZ_CP068808:1210889-1211308 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCCTTACTTCGTACGCTGATTGATCAACATAATTTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
TCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCATATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Structures

Toxin

• AlphaFold DB: A0A5R9QF16