Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 2788215..2788771 Replicon chromosome
Accession NZ_CP052845
Organism Bordetella hinzii strain 2B3

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag HHA24_RS12935 Protein ID WP_032978872.1
Coordinates 2788215..2788505 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HHA24_RS12940 Protein ID WP_032957511.1
Coordinates 2788493..2788771 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHA24_RS12920 (HHA24_12915) 2786476..2787258 - 783 WP_032978897.1 DUF1837 domain-containing protein -
HHA24_RS23555 (HHA24_12920) 2787484..2787942 - 459 WP_080700866.1 XRE family transcriptional regulator -
HHA24_RS12930 (HHA24_12925) 2787954..2788214 - 261 WP_032978875.1 hypothetical protein -
HHA24_RS12935 (HHA24_12930) 2788215..2788505 - 291 WP_032978872.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HHA24_RS12940 (HHA24_12935) 2788493..2788771 - 279 WP_032957511.1 CopG family ribbon-helix-helix protein Antitoxin
HHA24_RS12945 (HHA24_12940) 2788976..2789227 + 252 WP_032978869.1 hypothetical protein -
HHA24_RS12950 (HHA24_12945) 2789350..2790081 + 732 WP_032978894.1 recombinase family protein -
HHA24_RS12955 (HHA24_12950) 2790078..2790248 + 171 WP_155271649.1 hypothetical protein -
HHA24_RS12960 (HHA24_12955) 2790280..2790615 - 336 Protein_2569 AAA family ATPase -
HHA24_RS12965 (HHA24_12960) 2790618..2790755 - 138 Protein_2570 AlpA family phage regulatory protein -
HHA24_RS12970 (HHA24_12965) 2790876..2791118 - 243 Protein_2571 tyrosine-type recombinase/integrase -
HHA24_RS12980 (HHA24_12975) 2792443..2793411 - 969 Protein_2573 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2781081..2800382 19301


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10900.56 Da        Isoelectric Point: 9.5041

>T155592 WP_032978872.1 NZ_CP052845:c2788505-2788215 [Bordetella hinzii]
VPRLIWTPPAVADVQRLYRFLAPKDADAAQRAVKAIRAGVKILAHQPRIGRPVEDMEPEFREWLIDFGNSGYVALYRFDG
ENIAILAVRHQKEAGY

Download         Length: 291 bp

>T155592 NZ_CP068808:1117435-1117770 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAGCTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10801.20 Da        Isoelectric Point: 6.0964

>AT155592 WP_032957511.1 NZ_CP052845:c2788771-2788493 [Bordetella hinzii]
MARATSIKLDDELKGRVQHLAEARRRTSHWIMREAIAQYVEREEKREAFKQDALRAWEEYQRTGLHLTLEEADAWLAKLE
AGEDAELPKCHV

Download         Length: 279 bp

>AT155592 NZ_CP068808:1117187-1117435 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References