Detailed information of TA system TA155591

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 4322135..4322708
• Replicon: chromosome
• Accession: NZ_CP052844
• Organism: Bordetella hinzii strain 2G1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: W5IUR0
• Locus tag: HHA25_RS20505
• Protein ID: WP_009618209.1
• Coordinates: 4322421..4322708 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HHA25_RS20500
• Protein ID: WP_044061215.1
• Coordinates: 4322135..4322434 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHA25_RS20470 (HHA25_20470)	4317220..4317438	+	219	WP_009461157.1	AlpA family transcriptional regulator	-
HHA25_RS20475 (HHA25_20475)	4317480..4318346	+	867	WP_215600172.1	ParA family protein	-
HHA25_RS20480 (HHA25_20480)	4318330..4318578	+	249	WP_032972660.1	hypothetical protein	-
HHA25_RS20485 (HHA25_20485)	4318571..4320229	+	1659	WP_215600173.1	ParB family protein	-
HHA25_RS20490 (HHA25_20490)	4320247..4320807	+	561	WP_027350499.1	DUF2857 domain-containing protein	-
HHA25_RS20495 (HHA25_20495)	4320810..4322003	+	1194	WP_027350500.1	STY4528 family pathogenicity island replication protein	-
HHA25_RS20500 (HHA25_20500)	4322135..4322434	+	300	WP_044061215.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HHA25_RS20505 (HHA25_20505)	4322421..4322708	+	288	WP_009618209.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HHA25_RS20510 (HHA25_20510)	4322737..4322928	+	192	WP_027350501.1	hypothetical protein	-
HHA25_RS20515 (HHA25_20515)	4323052..4323831	+	780	WP_215600174.1	TIGR03761 family integrating conjugative element protein	-
HHA25_RS20520 (HHA25_20520)	4323828..4324376	+	549	WP_215600175.1	DUF3158 family protein	-
HHA25_RS20525 (HHA25_20525)	4324373..4324756	+	384	WP_027350504.1	single-stranded DNA-binding protein	-
HHA25_RS20530 (HHA25_20530)	4325038..4327053	+	2016	WP_215600176.1	DNA topoisomerase III	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-54)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10854.46 Da
• Isoelectric Point: 8.4628

>T155591 WP_009618209.1 NZ_CP052844:4322421-4322708 [Bordetella hinzii]
VRVLEWREAARADLLAIVDYISDDNPDAAQRLKDDIEAKAAKLPERPKLYRPGRVAGTREMVVRANYVVVYMEDTRAVSI
LRVLHAAQQWPPARE

Nucleotide

• Length: 288 bp

>T155591 NZ_CP068808:967465-967872 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10903.59 Da
• Isoelectric Point: 10.2615

>AT155591 WP_044061215.1 NZ_CP052844:4322135-4322434 [Bordetella hinzii]
MAAQTSMLHIRVDDKLKADAAEKLAGVGLTVSDAVRILLTRVVKEGALPAGLTADPEAYDAWFRAKVQEALADTRPPVRH
RQVMDEAQALIDRKRRART

Nucleotide

• Length: 300 bp

>AT155591 NZ_CP068808:967218-967484 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGATGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A5R9QF16