Detailed information of TA system TA155590

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2788235..2788791
• Replicon: chromosome
• Accession: NZ_CP052844
• Organism: Bordetella hinzii strain 2G1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HHA25_RS12940
• Protein ID: WP_032978872.1
• Coordinates: 2788235..2788525 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HHA25_RS12945
• Protein ID: WP_032957511.1
• Coordinates: 2788513..2788791 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHA25_RS12925 (HHA25_12920)	2786496..2787278	-	783	WP_032978897.1	DUF1837 domain-containing protein	-
HHA25_RS23570 (HHA25_12925)	2787504..2787962	-	459	WP_080700866.1	XRE family transcriptional regulator	-
HHA25_RS12935 (HHA25_12930)	2787974..2788234	-	261	WP_032978875.1	hypothetical protein	-
HHA25_RS12940 (HHA25_12935)	2788235..2788525	-	291	WP_032978872.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HHA25_RS12945 (HHA25_12940)	2788513..2788791	-	279	WP_032957511.1	CopG family ribbon-helix-helix protein	Antitoxin
HHA25_RS12950 (HHA25_12945)	2788996..2789247	+	252	WP_032978869.1	hypothetical protein	-
HHA25_RS12955 (HHA25_12950)	2789370..2790101	+	732	WP_032978894.1	recombinase family protein	-
HHA25_RS12960 (HHA25_12955)	2790098..2790268	+	171	WP_155271649.1	hypothetical protein	-
HHA25_RS12965 (HHA25_12960)	2790300..2790635	-	336	Protein_2570	AAA family ATPase	-
HHA25_RS12970 (HHA25_12965)	2790638..2790775	-	138	Protein_2571	AlpA family phage regulatory protein	-
HHA25_RS12975 (HHA25_12970)	2790896..2791138	-	243	Protein_2572	tyrosine-type recombinase/integrase	-
HHA25_RS12985 (HHA25_12980)	2792463..2793431	-	969	Protein_2574	integrase arm-type DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2781101..2800402	19301

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10900.56 Da
• Isoelectric Point: 9.5041

>T155590 WP_032978872.1 NZ_CP052844:c2788525-2788235 [Bordetella hinzii]
VPRLIWTPPAVADVQRLYRFLAPKDADAAQRAVKAIRAGVKILAHQPRIGRPVEDMEPEFREWLIDFGNSGYVALYRFDG
ENIAILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T155590 NZ_CP068808:c876487-876113 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGAAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10801.20 Da
• Isoelectric Point: 6.0964

>AT155590 WP_032957511.1 NZ_CP052844:c2788791-2788513 [Bordetella hinzii]
MARATSIKLDDELKGRVQHLAEARRRTSHWIMREAIAQYVEREEKREAFKQDALRAWEEYQRTGLHLTLEEADAWLAKLE
AGEDAELPKCHV

Nucleotide

• Length: 279 bp

>AT155590 NZ_CP068808:c876945-876577 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACTCATCCCGATGACAATCACGACCGTCCCTGGTGGGGACTACCCAGCACCGTGAC
GCCCTGTTTCGGGGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAAGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGTTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTTGCTGTTTATCCGACGCCCGAAACGAAACAGTAA