Detailed information of TA system TA155557

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4533158..4534416
• Replicon: chromosome
• Accession: NZ_CP052759
• Organism: Pseudomonas aeruginosa strain LYT4

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HH306_RS21125
• Protein ID: WP_003163133.1
• Coordinates: 4533158..4533913 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: HH306_RS21130
• Protein ID: WP_003086329.1
• Coordinates: 4534048..4534416 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HH306_RS21115	4528330..4530873	+	2544	WP_033981103.1	acyl-homoserine-lactone acylase QuiP	-
HH306_RS21120	4531028..4532389	-	1362	WP_003081943.1	DNA recombination protein RmuC	-
HH306_RS21125	4533158..4533913	-	756	WP_003163133.1	RES family NAD+ phosphorylase	Toxin
HH306_RS21130	4534048..4534416	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
HH306_RS21135	4534489..4535775	-	1287	WP_003163134.1	FAD-binding oxidoreductase	-
HH306_RS21140	4535831..4537420	-	1590	WP_003123191.1	aldehyde dehydrogenase family protein	-
HH306_RS21145	4537499..4537975	+	477	WP_003112531.1	hypothetical protein	-
HH306_RS21150	4537978..4538253	-	276	WP_010792073.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28250.37 Da
• Isoelectric Point: 7.7294

>T155557 WP_003163133.1 NZ_CP052759:c4533913-4533158 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T155557 NZ_CP068807:c969752-969498 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT155557 WP_003086329.1 NZ_CP052759:c4534416-4534048 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT155557 NZ_CP068807:c970000-969749 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Structures

Antitoxin

• AlphaFold DB: V6AJU7