Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3605167..3606388 Replicon chromosome
Accession NZ_CP052759
Organism Pseudomonas aeruginosa strain LYT4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HH306_RS16765 Protein ID WP_033981999.1
Coordinates 3605810..3606388 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HH306_RS16760 Protein ID WP_003088112.1
Coordinates 3605167..3605721 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HH306_RS16735 3600735..3601286 + 552 WP_004343115.1 XRE family transcriptional regulator -
HH306_RS16740 3601283..3601681 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
HH306_RS16745 3601694..3602017 - 324 WP_003102734.1 multidrug efflux SMR transporter -
HH306_RS16750 3602348..3602809 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
HH306_RS16755 3602814..3605009 + 2196 WP_016263578.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
HH306_RS16760 3605167..3605721 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
HH306_RS16765 3605810..3606388 + 579 WP_033981999.1 HD domain-containing protein Toxin
HH306_RS16770 3606497..3607684 - 1188 WP_021264658.1 HlyD family efflux transporter periplasmic adaptor subunit -
HH306_RS16775 3607674..3609845 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
HH306_RS16780 3609835..3611112 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21911.78 Da        Isoelectric Point: 5.3655

>T155556 WP_033981999.1 NZ_CP052759:3605810-3606388 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T155556 NZ_CP068807:957145-957519 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCTGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT155556 WP_003088112.1 NZ_CP052759:3605167-3605721 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT155556 NZ_CP068807:956688-957056 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References