Detailed information of TA system TA155553

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1362214..1362866
• Replicon: chromosome
• Accession: NZ_CP052757
• Organism: Cellulosimicrobium sp. BI34T

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FIC82_RS05845
• Protein ID: WP_168731530.1
• Coordinates: 1362214..1362636 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FIC82_RS05850
• Protein ID: WP_154797904.1
• Coordinates: 1362633..1362866 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIC82_RS05830	1357959..1359953	+	1995	WP_154797903.1	cell wall-binding repeat-containing protein	-
FIC82_RS05835	1360024..1360527	-	504	WP_087469863.1	inorganic diphosphatase	-
FIC82_RS05840	1360774..1362186	+	1413	WP_154799886.1	D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase	-
FIC82_RS05845	1362214..1362636	-	423	WP_168731530.1	type II toxin-antitoxin system VapC family toxin	Toxin
FIC82_RS05850	1362633..1362866	-	234	WP_154797904.1	antitoxin	Antitoxin
FIC82_RS05855	1362949..1364100	+	1152	WP_168731531.1	zinc-dependent metalloprotease	-
FIC82_RS05860	1364105..1365259	+	1155	WP_168731532.1	tRNA lysidine(34) synthetase TilS	-
FIC82_RS05865	1365265..1365819	+	555	WP_047233909.1	hypoxanthine phosphoribosyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

• SpoVT-AbrB domain (7-32)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 15114.22 Da
• Isoelectric Point: 5.2145

>T155553 WP_168731530.1 NZ_CP052757:c1362636-1362214 [Cellulosimicrobium sp. BI34T]
VSTLYLLDTNVLVALLRGSGAAARPRLREAEGRVAVSTVSEMELEYGIERSDDPHRNRQAVDDLLSLVDVLPFDGLAAMH
AGRVRALLAARGTPIGPYDALLAGHARSLGLVMVTNNLREFSRVPGLEVEDWLTGASREP

Nucleotide

• Length: 423 bp

>T155553 NZ_CP068807:238130-238306 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGCGTCACCCCAGCGAAGAGATTAAAGAACCATTGCGTAAAGCCATTCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8561.61 Da
• Isoelectric Point: 7.0133

>AT155553 WP_154797904.1 NZ_CP052757:c1362866-1362633 [Cellulosimicrobium sp. BI34T]
MVRTTVFRSNRTQAVRLPKAVALPDDVREVDVRAVGRSRVITPAGSGWDEWFDHGLRVAADFLPDRDQGTAEERGAL

Nucleotide

• Length: 234 bp

>AT155553 NZ_CP068807:238352-238768 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATCAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAAAT
TACTCGCTTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA