Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 220392..220987 Replicon plasmid pbghn2
Accession NZ_CP052134
Organism Burkholderia glumae strain HN

Toxin (Protein)


Gene name chpB Uniprot ID C5AN78
Locus tag GAS18_RS28285 Protein ID WP_012734107.1
Coordinates 220637..220987 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID C5AN79
Locus tag GAS18_RS28280 Protein ID WP_012734108.1
Coordinates 220392..220643 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GAS18_RS28245 216685..216921 + 237 WP_017924531.1 AbrB family transcriptional regulator -
GAS18_RS28250 216921..217322 + 402 WP_012735347.1 type II toxin-antitoxin system VapC family toxin -
GAS18_RS28255 217571..217900 + 330 WP_155297075.1 hypothetical protein -
GAS18_RS28260 217918..218163 + 246 WP_171467079.1 hypothetical protein -
GAS18_RS28265 218204..218932 - 729 WP_012735342.1 IS6 family transposase -
GAS18_RS28270 218975..219619 + 645 Protein_204 site-specific integrase -
GAS18_RS28275 219704..220129 + 426 WP_012734109.1 hypothetical protein -
GAS18_RS28280 220392..220643 + 252 WP_012734108.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GAS18_RS28285 220637..220987 + 351 WP_012734107.1 type II toxin-antitoxin system ChpB family toxin Toxin
GAS18_RS28290 221046..221240 + 195 WP_124837685.1 hypothetical protein -
GAS18_RS28295 221390..221611 + 222 WP_017433768.1 hypothetical protein -
GAS18_RS28300 221834..222298 + 465 WP_012734106.1 Lrp/AsnC family transcriptional regulator -
GAS18_RS28305 222600..224987 + 2388 WP_051071184.1 TonB-dependent receptor -
GAS18_RS28310 224977..225762 + 786 Protein_212 TonB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - tsr / tsr 1..281656 281656


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12389.37 Da        Isoelectric Point: 8.8909

>T155551 WP_012734107.1 NZ_CP052134:220637-220987 [Burkholderia glumae]
MVKRVKFERGDIVRVSLSPTVGREQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGSGTETQGVALV
NMVRMLDLEGRGARKIERAPVEVVEDALARLQTIIE

Download         Length: 351 bp

>T155551 NZ_CP068806:c4708649-4708464 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8940.31 Da        Isoelectric Point: 6.2420

>AT155551 WP_012734108.1 NZ_CP052134:220392-220643 [Burkholderia glumae]
MELKIQKWGNSAAVRLPSVLLEQINASVGGSLNADVRPDGVLLTPARRKYALDDLVAQCDTKAPVPADMAAWGEIKPVGR
EAW

Download         Length: 252 bp

>AT155551 NZ_CP068806:c4708447-4708037 [Escherichia coli]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGTGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTCCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCGAAAAGGTTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCAGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246MF70

Antitoxin

Source ID Structure
AlphaFold DB A0A246MFN5

References