Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 300463..301238 Replicon chromosome
Accession NZ_CP052133
Organism Burkholderia glumae strain HN

Toxin (Protein)


Gene name TacT2 Uniprot ID C5AIF4
Locus tag GAS18_RS17050 Protein ID WP_015877380.1
Coordinates 300463..300960 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID C5AIF5
Locus tag GAS18_RS17055 Protein ID WP_015877381.1
Coordinates 300957..301238 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GAS18_RS17020 295478..296530 - 1053 WP_124837861.1 RHS domain-containing protein -
GAS18_RS17025 296807..297184 - 378 WP_124837859.1 hypothetical protein -
GAS18_RS17030 297186..297632 - 447 WP_171467016.1 hypothetical protein -
GAS18_RS17035 297695..298790 - 1096 Protein_209 IS5 family transposase -
GAS18_RS17040 298878..299525 - 648 Protein_210 RHS domain-containing protein -
GAS18_RS17045 299885..300382 - 498 WP_015877379.1 ProQ activator of osmoprotectant transporter prop -
GAS18_RS17050 300463..300960 - 498 WP_015877380.1 GNAT family N-acetyltransferase Toxin
GAS18_RS17055 300957..301238 - 282 WP_015877381.1 DUF1778 domain-containing protein Antitoxin
GAS18_RS17060 301367..301645 - 279 Protein_214 sugar-binding protein -
GAS18_RS17065 301695..302057 - 363 WP_017432434.1 hypothetical protein -
GAS18_RS17070 302066..303127 - 1062 WP_171466868.1 RHS repeat-associated core domain-containing protein -
GAS18_RS17075 303237..303707 - 471 WP_171466869.1 SMI1/KNR4 family protein -
GAS18_RS17080 303817..304185 - 369 WP_124837592.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 286302..321489 35187


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-91)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17544.11 Da        Isoelectric Point: 9.6894

>T155548 WP_015877380.1 NZ_CP052133:c300960-300463 [Burkholderia glumae]
VTGWRAPEPLSDAHGLDDFDSGVASLDTWLKRRALANQRSGASRTFVATRDGRVGAYYALASGAVTLEVAPGRFRRNMPD
PIPVVVLGRLAVDRAHQGIGVGRALVRDAGLRVLHAAAAIGIRGLIVHALSDSAKAFYERVGFEASPLDPMLLLITLADL
EHALS

Download         Length: 498 bp

>T155548 NZ_CP068806:c4118482-4118186 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10256.52 Da        Isoelectric Point: 5.0477

>AT155548 WP_015877381.1 NZ_CP052133:c301238-300957 [Burkholderia glumae]
MTSTTPRDTLNLRIRPDDRSLIDRAAAAAHKTRTDFVLDAARAAAEQTLLDQVVLSAEPQAYAAFLARLDEPVQPNEALR
QTMQTRAPWDPAA

Download         Length: 282 bp

>AT155548 NZ_CP068806:c4118184-4117789 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9HNC8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9HNC9

References