Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2029531..2031126 Replicon chromosome
Accession NZ_CP052128
Organism Ralstonia solanacearum strain FJAT1303.F1

Toxin (Protein)


Gene name hipA Uniprot ID A0A0S4UDK5
Locus tag HI792_RS09335 Protein ID WP_069079583.1
Coordinates 2029789..2031126 (+) Length 446 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0S4UDK3
Locus tag HI792_RS09330 Protein ID WP_016725279.1
Coordinates 2029531..2029785 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HI792_RS09305 2025594..2026520 - 927 WP_016727232.1 muramoyltetrapeptide carboxypeptidase -
HI792_RS09310 2026517..2027068 - 552 WP_016727233.1 tRNA adenosine(34) deaminase TadA -
HI792_RS09315 2027088..2027564 - 477 WP_011001399.1 6-carboxytetrahydropterin synthase QueD -
HI792_RS09320 2027632..2028270 - 639 WP_020831956.1 7-carboxy-7-deazaguanine synthase -
HI792_RS09325 2028588..2029427 + 840 WP_016725278.1 oxaloacetate decarboxylase -
HI792_RS09330 2029531..2029785 + 255 WP_016725279.1 helix-turn-helix transcriptional regulator Antitoxin
HI792_RS09335 2029789..2031126 + 1338 WP_069079583.1 type II toxin-antitoxin system HipA family toxin Toxin
HI792_RS09340 2031123..2032325 + 1203 WP_064047701.1 MFS transporter -
HI792_RS09345 2032551..2033279 + 729 WP_011001393.1 DsbA family protein -
HI792_RS09350 2033292..2033855 - 564 WP_080606483.1 RNA 2',3'-cyclic phosphodiesterase -
HI792_RS09355 2034036..2034734 - 699 WP_016725453.1 protocatechuate 3,4-dioxygenase subunit alpha -
HI792_RS09360 2034731..2035471 - 741 WP_011001390.1 protocatechuate 3,4-dioxygenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-107)

Antitoxin

Transcription regulator, HipB-like

(10-66)


Sequences

Toxin        


Download         Length: 446 a.a.        Molecular weight: 48724.75 Da        Isoelectric Point: 6.7232

>T155542 WP_069079583.1 NZ_CP052128:2029789-2031126 [Ralstonia solanacearum]
MAHPELHLWMNGEHVGIWTASRAGVPILRYDDGWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVR
RRFGLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEPLTDSQVDTLLRNLTATPALGEDAGDPDAFRISIAGA
QEKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLAAWGLEVARTEIARFGASKVLAVERF
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRACLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFS
LAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLADIHVRHWQALAAQSGVPDAFAGMQALVE
RVPAGLERVEAILPPDFSGRVWSSVRTGVLAQAERFLNELASVTP

Download         Length: 1338 bp

>T155542 NZ_CP068806:c2084938-2084831 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8754.07 Da        Isoelectric Point: 10.4693

>AT155542 WP_016725279.1 NZ_CP052128:2029531-2029785 [Ralstonia solanacearum]
MESLLSSAPQLSAHLKSLRKARGLTQAQLGALLGVSQNRIADIEKDPGAVGFEQLLRILHALGAQLTLRTSAPAGTPSAA
PADW

Download         Length: 255 bp

>AT155542 NZ_CP068806:2084991-2085052 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S4UDK5

Antitoxin

Source ID Structure
AlphaFold DB A0A0S4UDK3

References