Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 439784..440417 Replicon chromosome
Accession NZ_CP052128
Organism Ralstonia solanacearum strain FJAT1303.F1

Toxin (Protein)


Gene name vapC Uniprot ID M4UIT8
Locus tag HI792_RS02055 Protein ID WP_016725172.1
Coordinates 440004..440417 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q8XUX7
Locus tag HI792_RS02050 Protein ID WP_011002949.1
Coordinates 439784..440017 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HI792_RS02035 435372..436667 - 1296 WP_011002952.1 MFS transporter -
HI792_RS02040 436675..437925 - 1251 WP_089190599.1 AGE family epimerase/isomerase -
HI792_RS02045 438120..439727 + 1608 WP_058908048.1 glucan biosynthesis protein -
HI792_RS02050 439784..440017 + 234 WP_011002949.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HI792_RS02055 440004..440417 + 414 WP_016725172.1 PIN domain-containing protein Toxin
HI792_RS02060 440392..441018 - 627 WP_058908047.1 DUF1415 domain-containing protein -
HI792_RS02065 441209..441580 + 372 WP_011002946.1 hypothetical protein -
HI792_RS02070 441641..443137 - 1497 WP_011002945.1 glycerol kinase GlpK -
HI792_RS02075 443299..445035 - 1737 WP_058908046.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-116)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15087.42 Da        Isoelectric Point: 5.5348

>T155541 WP_016725172.1 NZ_CP052128:440004-440417 [Ralstonia solanacearum]
MPATEAFFDSNVVLYLLSADTAKADAAETLLMTGGVVSVQVLNETTHVMRRKLAMPWHAIETVQEAVRAQCRVEPLTLET
HDLGRRIAERYGLSVYDALIVAAALLAGCNVLYSEDMQHGLVIEQHLRIVNPFPARA

Download         Length: 414 bp

>T155541 NZ_CP068806:c2084403-2084296 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8790.98 Da        Isoelectric Point: 8.7287

>AT155541 WP_011002949.1 NZ_CP052128:439784-440017 [Ralstonia solanacearum]
MQVSKWGNSLAIRLPAAVVEALQLHEGDDVEVVIAGERSFGVRRKRAARELFDRIHQYRGKLPADFIFERDQANARD

Download         Length: 234 bp

>AT155541 NZ_CP068806:2084451-2084517 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4UIT8

Antitoxin

Source ID Structure
AlphaFold DB A0A223GR76

References