Detailed information of TA system TA155510

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2209831..2211426
• Replicon: chromosome
• Accession: NZ_CP052112
• Organism: Ralstonia solanacearum strain FJAT15244.F1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HI801_RS10345
• Protein ID: WP_086706272.1
• Coordinates: 2210089..2211426 (+)
• Length: 446 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0S4UDK3
• Locus tag: HI801_RS10340
• Protein ID: WP_016725279.1
• Coordinates: 2209831..2210085 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HI801_RS10315	2205894..2206820	-	927	WP_016727232.1	muramoyltetrapeptide carboxypeptidase	-
HI801_RS10320	2206817..2207368	-	552	WP_016727233.1	tRNA adenosine(34) deaminase TadA	-
HI801_RS10325	2207388..2207864	-	477	WP_011001399.1	6-carboxytetrahydropterin synthase QueD	-
HI801_RS10330	2207932..2208570	-	639	WP_020831956.1	7-carboxy-7-deazaguanine synthase	-
HI801_RS10335	2208888..2209727	+	840	WP_016725278.1	oxaloacetate decarboxylase	-
HI801_RS10340	2209831..2210085	+	255	WP_016725279.1	helix-turn-helix transcriptional regulator	Antitoxin
HI801_RS10345	2210089..2211426	+	1338	WP_086706272.1	type II toxin-antitoxin system HipA family toxin	Toxin
HI801_RS10350	2211423..2212625	+	1203	WP_011001394.1	MFS transporter	-
HI801_RS10355	2212851..2213579	+	729	WP_021155798.1	DsbA family protein	-
HI801_RS10360	2213592..2214155	-	564	WP_080624831.1	RNA 2',3'-cyclic phosphodiesterase	-
HI801_RS10365	2214336..2215034	-	699	WP_016725453.1	protocatechuate 3,4-dioxygenase subunit alpha	-
HI801_RS10370	2215031..2215771	-	741	WP_011001390.1	protocatechuate 3,4-dioxygenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-107)

Antitoxin

• Transcription regulator, HipB-like (10-66)

Sequences

Toxin

Protein

• Length: 446 a.a.
• Molecular weight: 48754.78 Da
• Isoelectric Point: 6.7232

>T155510 WP_086706272.1 NZ_CP052112:2210089-2211426 [Ralstonia solanacearum]
MAHPELHLWMNGEHVGIWTASRAGVPILRYDDGWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVR
RRFGLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEPLTDSQVDTLLRNLTATPALGEDAGDPDAFRISIAGA
QEKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLAAWGLEVARTEIARFGTSKVLAVERF
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRACLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFS
LAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLADIHVRHWQALAAQSGVPDAFAGMQALVE
RVPAGLERVEAILPPDFSGRVWSSVRTGVLAQAERFLNELASVTP

Nucleotide

• Length: 1338 bp

>T155510 NZ_CP068805:c1110373-1110038 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAGCTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 8754.07 Da
• Isoelectric Point: 10.4693

>AT155510 WP_016725279.1 NZ_CP052112:2209831-2210085 [Ralstonia solanacearum]
MESLLSSAPQLSAHLKSLRKARGLTQAQLGALLGVSQNRIADIEKDPGAVGFEQLLRILHALGAQLTLRTSAPAGTPSAA
PADW

Nucleotide

• Length: 255 bp

>AT155510 NZ_CP068805:c1110621-1110373 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0S4UDK3