Detailed information of TA system TA155507

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2209830..2211425
• Replicon: chromosome
• Accession: NZ_CP052110
• Organism: Ralstonia solanacearum strain FJAT15244.F50

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HI802_RS10340
• Protein ID: WP_086706272.1
• Coordinates: 2210088..2211425 (+)
• Length: 446 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0S4UDK3
• Locus tag: HI802_RS10335
• Protein ID: WP_016725279.1
• Coordinates: 2209830..2210084 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HI802_RS10310	2205893..2206819	-	927	WP_016727232.1	muramoyltetrapeptide carboxypeptidase	-
HI802_RS10315	2206816..2207367	-	552	WP_016727233.1	tRNA adenosine(34) deaminase TadA	-
HI802_RS10320	2207387..2207863	-	477	WP_011001399.1	6-carboxytetrahydropterin synthase QueD	-
HI802_RS10325	2207931..2208569	-	639	WP_020831956.1	7-carboxy-7-deazaguanine synthase	-
HI802_RS10330	2208887..2209726	+	840	WP_016725278.1	oxaloacetate decarboxylase	-
HI802_RS10335	2209830..2210084	+	255	WP_016725279.1	helix-turn-helix transcriptional regulator	Antitoxin
HI802_RS10340	2210088..2211425	+	1338	WP_086706272.1	type II toxin-antitoxin system HipA family toxin	Toxin
HI802_RS10345	2211422..2212624	+	1203	WP_011001394.1	MFS transporter	-
HI802_RS10350	2212850..2213578	+	729	WP_021155798.1	DsbA family protein	-
HI802_RS10355	2213591..2214154	-	564	WP_080624831.1	RNA 2',3'-cyclic phosphodiesterase	-
HI802_RS10360	2214335..2215033	-	699	WP_016725453.1	protocatechuate 3,4-dioxygenase subunit alpha	-
HI802_RS10365	2215030..2215770	-	741	WP_011001390.1	protocatechuate 3,4-dioxygenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-107)

Antitoxin

• Transcription regulator, HipB-like (10-66)

Sequences

Toxin

Protein

• Length: 446 a.a.
• Molecular weight: 48754.78 Da
• Isoelectric Point: 6.7232

>T155507 WP_086706272.1 NZ_CP052110:2210088-2211425 [Ralstonia solanacearum]
MAHPELHLWMNGEHVGIWTASRAGVPILRYDDGWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVR
RRFGLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEPLTDSQVDTLLRNLTATPALGEDAGDPDAFRISIAGA
QEKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLAAWGLEVARTEIARFGTSKVLAVERF
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRACLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFS
LAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLADIHVRHWQALAAQSGVPDAFAGMQALVE
RVPAGLERVEAILPPDFSGRVWSSVRTGVLAQAERFLNELASVTP

Nucleotide

• Length: 1338 bp

>T155507 NZ_CP068805:259418-259525 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 8754.07 Da
• Isoelectric Point: 10.4693

>AT155507 WP_016725279.1 NZ_CP052110:2209830-2210084 [Ralstonia solanacearum]
MESLLSSAPQLSAHLKSLRKARGLTQAQLGALLGVSQNRIADIEKDPGAVGFEQLLRILHALGAQLTLRTSAPAGTPSAA
PADW

Nucleotide

• Length: 255 bp

>AT155507 NZ_CP068805:c259369-259306 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Structures

Antitoxin

• AlphaFold DB: A0A0S4UDK3