Detailed information of TA system TA155497

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1965350..1965944
• Replicon: chromosome
• Accession: NZ_CP052106
• Organism: Ralstonia solanacearum strain FJAT15249.F50

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: G3A6N4
• Locus tag: HI804_RS09540
• Protein ID: WP_016721901.1
• Coordinates: 1965681..1965944 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HI804_RS09535
• Protein ID: WP_038961924.1
• Coordinates: 1965350..1965688 (-)
• Length: 113 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HI804_RS09505	1961732..1962070	+	339	WP_016721894.1	phage tail protein	-
HI804_RS09510	1962067..1962744	+	678	WP_016721895.1	phage tail protein	-
HI804_RS09515	1962750..1963346	+	597	WP_016721896.1	tail fiber assembly protein	-
HI804_RS09520	1963343..1964044	+	702	WP_071895496.1	phage minor tail protein L	-
HI804_RS09525	1964046..1964756	+	711	WP_071895497.1	C40 family peptidase	-
HI804_RS09530	1964760..1965353	+	594	WP_016721899.1	tail assembly protein	-
HI804_RS09535	1965350..1965688	-	339	WP_038961924.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HI804_RS09540	1965681..1965944	-	264	WP_016721901.1	type II toxin-antitoxin system HicA family toxin	Toxin
HI804_RS09545	1965997..1969152	+	3156	WP_016721902.1	host specificity protein J	-
HI804_RS09550	1969489..1970145	+	657	WP_038961925.1	hypothetical protein	-
HI804_RS09555	1970214..1970705	+	492	WP_038961926.1	glycoside hydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1895918..2024615	128697

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-75)

Antitoxin

• Uncharacterised protein family HicB (56-105)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 9834.30 Da
• Isoelectric Point: 8.7458

>T155497 WP_016721901.1 NZ_CP052106:c1965944-1965681 [Ralstonia solanacearum]
MKAKHKKTLDLIFSRPTPAGVKWNDLVGLLVELGAEITEREGSRVAVFLFNQVKVMHRPHPSPDVDKGAVASIRKWLEDN
ATEWNNE

Nucleotide

• Length: 264 bp

>T155497 NZ_CP068804:c4410057-4409848 [Escherichia coli]
ATGGTTGATTATCCAAAACGTGATGCTATTTCCAACATCAACGCTATAATTGTAGATACATTTTTGTATATACAATTAGG
GATGGCAACTATGCCAATGGAGTTTGAATGGAATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTG
AAGATGCGGTGTTAGTGCTTGATGATCCACAACGAACGGAGCCGCTATGA

Antitoxin

Protein

• Length: 113 a.a.
• Molecular weight: 12183.80 Da
• Isoelectric Point: 4.8946

>AT155497 WP_038961924.1 NZ_CP052106:c1965688-1965350 [Ralstonia solanacearum]
MNNVMIIGGEKAVISFDPELEMFRGEFIGLNGGADFYASDVAGLHREGELSLRTFMEECVRRGVEPRRSFSGKFVLRTSE
KTHEAAAIAAAAHGVSLNQWVSDVIEQAAIPA

Nucleotide

• Length: 339 bp

>AT155497 NZ_CP068804:c4409851-4409549 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGTGCTGGCGAA
CAAATTCGACGAGGATATTGATTACAGCGACATCCCATCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Structures

Toxin

• AlphaFold DB: G3A6N4