Detailed information of TA system TA155487

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1965356..1965950
• Replicon: chromosome
• Accession: NZ_CP052102
• Organism: Ralstonia solanacearum strain FJAT15252.F50

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: G3A6N4
• Locus tag: HI806_RS09530
• Protein ID: WP_016721901.1
• Coordinates: 1965687..1965950 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HI806_RS09525
• Protein ID: WP_038961924.1
• Coordinates: 1965356..1965694 (-)
• Length: 113 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HI806_RS09495	1961738..1962076	+	339	WP_016721894.1	phage tail protein	-
HI806_RS09500	1962073..1962750	+	678	WP_016721895.1	phage tail protein	-
HI806_RS09505	1962756..1963352	+	597	WP_016721896.1	tail fiber assembly protein	-
HI806_RS09510	1963349..1964050	+	702	WP_071895496.1	phage minor tail protein L	-
HI806_RS09515	1964052..1964762	+	711	WP_071895497.1	C40 family peptidase	-
HI806_RS09520	1964766..1965359	+	594	WP_016721899.1	tail assembly protein	-
HI806_RS09525	1965356..1965694	-	339	WP_038961924.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HI806_RS09530	1965687..1965950	-	264	WP_016721901.1	type II toxin-antitoxin system HicA family toxin	Toxin
HI806_RS09535	1966003..1969158	+	3156	WP_016721902.1	host specificity protein J	-
HI806_RS09540	1969495..1970151	+	657	WP_038961925.1	hypothetical protein	-
HI806_RS09545	1970220..1970711	+	492	WP_038961926.1	glycoside hydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1895924..1988943	93019

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-75)

Antitoxin

• Uncharacterised protein family HicB (56-105)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 9834.30 Da
• Isoelectric Point: 8.7458

>T155487 WP_016721901.1 NZ_CP052102:c1965950-1965687 [Ralstonia solanacearum]
MKAKHKKTLDLIFSRPTPAGVKWNDLVGLLVELGAEITEREGSRVAVFLFNQVKVMHRPHPSPDVDKGAVASIRKWLEDN
ATEWNNE

Nucleotide

• Length: 264 bp

>T155487 NZ_CP068804:2285315-2285418 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 113 a.a.
• Molecular weight: 12183.80 Da
• Isoelectric Point: 4.8946

>AT155487 WP_038961924.1 NZ_CP052102:c1965694-1965356 [Ralstonia solanacearum]
MNNVMIIGGEKAVISFDPELEMFRGEFIGLNGGADFYASDVAGLHREGELSLRTFMEECVRRGVEPRRSFSGKFVLRTSE
KTHEAAAIAAAAHGVSLNQWVSDVIEQAAIPA

Nucleotide

• Length: 339 bp

>AT155487 NZ_CP068804:c2285456-2285185 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGCCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Toxin

• AlphaFold DB: G3A6N4