Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1942049..1942638 Replicon chromosome
Accession NZ_CP052086
Organism Ralstonia solanacearum strain FJAT15353.F50

Toxin (Protein)


Gene name hicA Uniprot ID A0A1U9VH68
Locus tag HI814_RS09130 Protein ID WP_072633588.1
Coordinates 1942384..1942638 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1U9VFS6
Locus tag HI814_RS09125 Protein ID WP_028853154.1
Coordinates 1942049..1942387 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HI814_RS09095 1938391..1938729 + 339 WP_072633583.1 phage tail protein -
HI814_RS09100 1938726..1939361 + 636 WP_072633584.1 phage tail protein -
HI814_RS09105 1939367..1939963 + 597 WP_072633585.1 tail fiber assembly protein -
HI814_RS09110 1939960..1940661 + 702 WP_072633586.1 phage minor tail protein L -
HI814_RS09115 1940663..1941373 + 711 WP_072633587.1 C40 family peptidase -
HI814_RS09120 1941377..1941979 + 603 WP_072633645.1 tail assembly protein -
HI814_RS09125 1942049..1942387 - 339 WP_028853154.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HI814_RS09130 1942384..1942638 - 255 WP_072633588.1 type II toxin-antitoxin system HicA family toxin Toxin
HI814_RS09135 1942689..1945844 + 3156 WP_173941551.1 host specificity protein J -
HI814_RS09140 1946181..1946837 + 657 WP_028853157.1 hypothetical protein -
HI814_RS09145 1946906..1947397 + 492 WP_011001641.1 glycoside hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1926510..1960104 33594


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9488.05 Da        Isoelectric Point: 10.3121

>T155457 WP_072633588.1 NZ_CP052086:c1942638-1942384 [Ralstonia solanacearum]
MKAKHQKTLELIFSRPTPAGVKWADAVTLMRELGAELEEREGSRVAVFLFGQVKVMHRPHPSPDMDKGAVASMRKWFEEN
GVKP

Download         Length: 255 bp

>T155457 NZ_CP068803:c621043-620579 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 11968.58 Da        Isoelectric Point: 5.1375

>AT155457 WP_028853154.1 NZ_CP052086:c1942387-1942049 [Ralstonia solanacearum]
MINVMNIGGHKAVIAYDPDIEMFRGEFVGLNGGADFYAADVTGLHREGELSLRVFLEECARRGVEPQKHFSGKFVLRVEG
KVHEAAAIAAAAQGVSLNQWAAGVLEQAAEAA

Download         Length: 339 bp

>AT155457 NZ_CP068803:c621378-621043 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9VH68

Antitoxin

Source ID Structure
AlphaFold DB A0A1U9VFS6

References