Detailed information of TA system TA155451

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2187696..2189291
• Replicon: chromosome
• Accession: NZ_CP052082
• Organism: Ralstonia solanacearum strain FJAT442.F1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A9E8CN90
• Locus tag: HI816_RS09935
• Protein ID: WP_064047702.1
• Coordinates: 2187954..2189291 (+)
• Length: 446 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A9E8CGB2
• Locus tag: HI816_RS09930
• Protein ID: WP_064047703.1
• Coordinates: 2187696..2187950 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HI816_RS09905	2183760..2184686	-	927	WP_020831958.1	muramoyltetrapeptide carboxypeptidase	-
HI816_RS09910	2184683..2185234	-	552	WP_028860693.1	tRNA adenosine(34) deaminase TadA	-
HI816_RS09915	2185254..2185730	-	477	WP_011001399.1	6-carboxytetrahydropterin synthase QueD	-
HI816_RS09920	2185798..2186436	-	639	WP_020831956.1	7-carboxy-7-deazaguanine synthase	-
HI816_RS09925	2186754..2187593	+	840	WP_020831955.1	isocitrate lyase/phosphoenolpyruvate mutase family protein	-
HI816_RS09930	2187696..2187950	+	255	WP_064047703.1	helix-turn-helix transcriptional regulator	Antitoxin
HI816_RS09935	2187954..2189291	+	1338	WP_064047702.1	type II toxin-antitoxin system HipA family toxin	Toxin
HI816_RS09940	2189288..2190490	+	1203	WP_064047701.1	MFS transporter	-
HI816_RS09945	2190716..2191444	+	729	WP_020831952.1	DsbA family protein	-
HI816_RS09950	2191457..2192020	-	564	WP_080511083.1	RNA 2',3'-cyclic phosphodiesterase	-
HI816_RS09955	2192201..2192899	-	699	WP_043897706.1	protocatechuate 3,4-dioxygenase subunit alpha	-
HI816_RS09960	2192896..2193636	-	741	WP_011001390.1	protocatechuate 3,4-dioxygenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-107)

Antitoxin

• Transcription regulator, HipB-like (10-66)

Sequences

Toxin

Protein

• Length: 446 a.a.
• Molecular weight: 48768.81 Da
• Isoelectric Point: 6.7232

>T155451 WP_064047702.1 NZ_CP052082:2187954-2189291 [Ralstonia solanacearum]
MAHPELHLWMNGEHVGIWTASRAGVPILRYDDAWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVR
RRFGLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEPLTDSQVDTLLRNLTATPALGEDAGDPDAFRISIAGA
QEKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLAAWGLEVARTEIARFGTSKVLAVERF
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRACLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFS
LAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLADIHVRHWQALAAQSGVPDAFAGMQALVE
RVPAGLERVEAILPPDFSGRVWSSVRTGVLAQAERFLNELASVTP

Nucleotide

• Length: 1338 bp

>T155451 NZ_CP068802:c2693346-2693173 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTAGGAATAACCTGGCCAATGAGTTTACCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 8780.11 Da
• Isoelectric Point: 10.0897

>AT155451 WP_064047703.1 NZ_CP052082:2187696-2187950 [Ralstonia solanacearum]
MESLLSSAPQLSAHLKSLRKARGLTQAQLGALLGVSQNRIADIEKDPGAVGFEQLLRILYALGAQLTLRTSAPAGTPSAA
PADW

Nucleotide

• Length: 255 bp

>AT155451 NZ_CP068802:c2693670-2693374 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGCATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCATTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG