Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2187697..2189292 Replicon chromosome
Accession NZ_CP052080
Organism Ralstonia solanacearum strain FJAT442.F50

Toxin (Protein)


Gene name hipA Uniprot ID A0A9E8CN90
Locus tag HI817_RS09930 Protein ID WP_064047702.1
Coordinates 2187955..2189292 (+) Length 446 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A9E8CGB2
Locus tag HI817_RS09925 Protein ID WP_064047703.1
Coordinates 2187697..2187951 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HI817_RS09900 2183761..2184687 - 927 WP_020831958.1 muramoyltetrapeptide carboxypeptidase -
HI817_RS09905 2184684..2185235 - 552 WP_028860693.1 tRNA adenosine(34) deaminase TadA -
HI817_RS09910 2185255..2185731 - 477 WP_011001399.1 6-carboxytetrahydropterin synthase QueD -
HI817_RS09915 2185799..2186437 - 639 WP_020831956.1 7-carboxy-7-deazaguanine synthase -
HI817_RS09920 2186755..2187594 + 840 WP_020831955.1 isocitrate lyase/phosphoenolpyruvate mutase family protein -
HI817_RS09925 2187697..2187951 + 255 WP_064047703.1 helix-turn-helix transcriptional regulator Antitoxin
HI817_RS09930 2187955..2189292 + 1338 WP_064047702.1 type II toxin-antitoxin system HipA family toxin Toxin
HI817_RS09935 2189289..2190491 + 1203 WP_064047701.1 MFS transporter -
HI817_RS09940 2190717..2191445 + 729 WP_020831952.1 DsbA family protein -
HI817_RS09945 2191458..2192021 - 564 WP_080511083.1 RNA 2',3'-cyclic phosphodiesterase -
HI817_RS09950 2192202..2192900 - 699 WP_043897706.1 protocatechuate 3,4-dioxygenase subunit alpha -
HI817_RS09955 2192897..2193637 - 741 WP_011001390.1 protocatechuate 3,4-dioxygenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-107)

Antitoxin

Transcription regulator, HipB-like

(10-66)


Sequences

Toxin        


Download         Length: 446 a.a.        Molecular weight: 48768.81 Da        Isoelectric Point: 6.7232

>T155448 WP_064047702.1 NZ_CP052080:2187955-2189292 [Ralstonia solanacearum]
MAHPELHLWMNGEHVGIWTASRAGVPILRYDDAWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVR
RRFGLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEPLTDSQVDTLLRNLTATPALGEDAGDPDAFRISIAGA
QEKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLAAWGLEVARTEIARFGTSKVLAVERF
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRACLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFS
LAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLADIHVRHWQALAAQSGVPDAFAGMQALVE
RVPAGLERVEAILPPDFSGRVWSSVRTGVLAQAERFLNELASVTP

Download         Length: 1338 bp

>T155448 NZ_CP068802:2386692-2386844 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8780.11 Da        Isoelectric Point: 10.0897

>AT155448 WP_064047703.1 NZ_CP052080:2187697-2187951 [Ralstonia solanacearum]
MESLLSSAPQLSAHLKSLRKARGLTQAQLGALLGVSQNRIADIEKDPGAVGFEQLLRILYALGAQLTLRTSAPAGTPSAA
PADW

Download         Length: 255 bp

>AT155448 NZ_CP068802:c2386643-2386586 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References