Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2187407..2189002 Replicon chromosome
Accession NZ_CP052076
Organism Ralstonia solanacearum strain FJAT445.F50

Toxin (Protein)


Gene name hipA Uniprot ID A0A9E8CN90
Locus tag HI819_RS09935 Protein ID WP_064047702.1
Coordinates 2187665..2189002 (+) Length 446 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A9E8CGB2
Locus tag HI819_RS09930 Protein ID WP_064047703.1
Coordinates 2187407..2187661 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HI819_RS09905 2183471..2184397 - 927 WP_020831958.1 muramoyltetrapeptide carboxypeptidase -
HI819_RS09910 2184394..2184945 - 552 WP_028860693.1 tRNA adenosine(34) deaminase TadA -
HI819_RS09915 2184965..2185441 - 477 WP_011001399.1 6-carboxytetrahydropterin synthase QueD -
HI819_RS09920 2185509..2186147 - 639 WP_020831956.1 7-carboxy-7-deazaguanine synthase -
HI819_RS09925 2186465..2187304 + 840 WP_020831955.1 isocitrate lyase/phosphoenolpyruvate mutase family protein -
HI819_RS09930 2187407..2187661 + 255 WP_064047703.1 helix-turn-helix transcriptional regulator Antitoxin
HI819_RS09935 2187665..2189002 + 1338 WP_064047702.1 type II toxin-antitoxin system HipA family toxin Toxin
HI819_RS09940 2188999..2190201 + 1203 WP_064047701.1 MFS transporter -
HI819_RS09945 2190427..2191155 + 729 WP_020831952.1 DsbA family protein -
HI819_RS09950 2191168..2191731 - 564 WP_080511083.1 RNA 2',3'-cyclic phosphodiesterase -
HI819_RS09955 2191912..2192610 - 699 WP_043897706.1 protocatechuate 3,4-dioxygenase subunit alpha -
HI819_RS09960 2192607..2193347 - 741 WP_011001390.1 protocatechuate 3,4-dioxygenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-107)

Antitoxin

Transcription regulator, HipB-like

(10-66)


Sequences

Toxin        


Download         Length: 446 a.a.        Molecular weight: 48768.81 Da        Isoelectric Point: 6.7232

>T155442 WP_064047702.1 NZ_CP052076:2187665-2189002 [Ralstonia solanacearum]
MAHPELHLWMNGEHVGIWTASRAGVPILRYDDAWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVR
RRFGLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEPLTDSQVDTLLRNLTATPALGEDAGDPDAFRISIAGA
QEKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLAAWGLEVARTEIARFGTSKVLAVERF
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRACLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFS
LAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLADIHVRHWQALAAQSGVPDAFAGMQALVE
RVPAGLERVEAILPPDFSGRVWSSVRTGVLAQAERFLNELASVTP

Download         Length: 1338 bp

>T155442 NZ_CP068802:977709-977816 [Escherichia coli]
ATGACGCTCACGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAACACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8780.11 Da        Isoelectric Point: 10.0897

>AT155442 WP_064047703.1 NZ_CP052076:2187407-2187661 [Ralstonia solanacearum]
MESLLSSAPQLSAHLKSLRKARGLTQAQLGALLGVSQNRIADIEKDPGAVGFEQLLRILYALGAQLTLRTSAPAGTPSAA
PADW

Download         Length: 255 bp

>AT155442 NZ_CP068802:c977659-977596 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References