Detailed information of TA system TA155437

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1925113..1925707
• Replicon: chromosome
• Accession: NZ_CP052074
• Organism: Ralstonia solanacearum strain FJAT448.F1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: G3A6N4
• Locus tag: HI820_RS09245
• Protein ID: WP_016721901.1
• Coordinates: 1925444..1925707 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HI820_RS09240
• Protein ID: WP_038961924.1
• Coordinates: 1925113..1925451 (-)
• Length: 113 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HI820_RS09210	1921495..1921833	+	339	WP_016721894.1	phage tail protein	-
HI820_RS09215	1921830..1922507	+	678	WP_016721895.1	phage tail protein	-
HI820_RS09220	1922513..1923109	+	597	WP_016721896.1	tail fiber assembly protein	-
HI820_RS09225	1923106..1923807	+	702	WP_071895496.1	phage minor tail protein L	-
HI820_RS09230	1923809..1924519	+	711	WP_071895497.1	C40 family peptidase	-
HI820_RS09235	1924523..1925116	+	594	WP_016721899.1	tail assembly protein	-
HI820_RS09240	1925113..1925451	-	339	WP_038961924.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HI820_RS09245	1925444..1925707	-	264	WP_016721901.1	type II toxin-antitoxin system HicA family toxin	Toxin
HI820_RS09250	1925760..1928915	+	3156	WP_016721902.1	host specificity protein J	-
HI820_RS09255	1929252..1929908	+	657	WP_038961925.1	hypothetical protein	-
HI820_RS09260	1929977..1930468	+	492	WP_038961926.1	glycoside hydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1855681..1939891	84210

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-75)

Antitoxin

• Uncharacterised protein family HicB (56-105)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 9834.30 Da
• Isoelectric Point: 8.7458

>T155437 WP_016721901.1 NZ_CP052074:c1925707-1925444 [Ralstonia solanacearum]
MKAKHKKTLDLIFSRPTPAGVKWNDLVGLLVELGAEITEREGSRVAVFLFNQVKVMHRPHPSPDVDKGAVASIRKWLEDN
ATEWNNE

Nucleotide

• Length: 264 bp

>T155437 NZ_CP068802:107595-107846 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTAAGTGA

Antitoxin

Protein

• Length: 113 a.a.
• Molecular weight: 12183.80 Da
• Isoelectric Point: 4.8946

>AT155437 WP_038961924.1 NZ_CP052074:c1925451-1925113 [Ralstonia solanacearum]
MNNVMIIGGEKAVISFDPELEMFRGEFIGLNGGADFYASDVAGLHREGELSLRTFMEECVRRGVEPRRSFSGKFVLRTSE
KTHEAAAIAAAAHGVSLNQWVSDVIEQAAIPA

Nucleotide

• Length: 339 bp

>AT155437 NZ_CP068802:107843-108097 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Toxin

• AlphaFold DB: G3A6N4