Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2217621..2219216 Replicon chromosome
Accession NZ_CP052072
Organism Ralstonia solanacearum strain FJAT448.F50

Toxin (Protein)


Gene name hipA Uniprot ID A0A0S4UDK5
Locus tag HI821_RS10340 Protein ID WP_069079583.1
Coordinates 2217879..2219216 (+) Length 446 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0S4UDK3
Locus tag HI821_RS10335 Protein ID WP_016725279.1
Coordinates 2217621..2217875 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HI821_RS10310 2213684..2214610 - 927 WP_016727232.1 muramoyltetrapeptide carboxypeptidase -
HI821_RS10315 2214607..2215158 - 552 WP_016727233.1 tRNA adenosine(34) deaminase TadA -
HI821_RS10320 2215178..2215654 - 477 WP_011001399.1 6-carboxytetrahydropterin synthase QueD -
HI821_RS10325 2215722..2216360 - 639 WP_020831956.1 7-carboxy-7-deazaguanine synthase -
HI821_RS10330 2216678..2217517 + 840 WP_016725278.1 oxaloacetate decarboxylase -
HI821_RS10335 2217621..2217875 + 255 WP_016725279.1 helix-turn-helix transcriptional regulator Antitoxin
HI821_RS10340 2217879..2219216 + 1338 WP_069079583.1 type II toxin-antitoxin system HipA family toxin Toxin
HI821_RS10345 2219213..2220415 + 1203 WP_064047701.1 MFS transporter -
HI821_RS10350 2220641..2221369 + 729 WP_011001393.1 DsbA family protein -
HI821_RS10355 2221382..2221945 - 564 WP_080606483.1 RNA 2',3'-cyclic phosphodiesterase -
HI821_RS10360 2222126..2222824 - 699 WP_016725453.1 protocatechuate 3,4-dioxygenase subunit alpha -
HI821_RS10365 2222821..2223561 - 741 WP_011001390.1 protocatechuate 3,4-dioxygenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-107)

Antitoxin

Transcription regulator, HipB-like

(10-66)


Sequences

Toxin        


Download         Length: 446 a.a.        Molecular weight: 48724.75 Da        Isoelectric Point: 6.7232

>T155433 WP_069079583.1 NZ_CP052072:2217879-2219216 [Ralstonia solanacearum]
MAHPELHLWMNGEHVGIWTASRAGVPILRYDDGWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVR
RRFGLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEPLTDSQVDTLLRNLTATPALGEDAGDPDAFRISIAGA
QEKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLAAWGLEVARTEIARFGASKVLAVERF
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRACLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFS
LAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLADIHVRHWQALAAQSGVPDAFAGMQALVE
RVPAGLERVEAILPPDFSGRVWSSVRTGVLAQAERFLNELASVTP

Download         Length: 1338 bp

>T155433 NZ_CP068801:c4666502-4666152 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGTGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8754.07 Da        Isoelectric Point: 10.4693

>AT155433 WP_016725279.1 NZ_CP052072:2217621-2217875 [Ralstonia solanacearum]
MESLLSSAPQLSAHLKSLRKARGLTQAQLGALLGVSQNRIADIEKDPGAVGFEQLLRILHALGAQLTLRTSAPAGTPSAA
PADW

Download         Length: 255 bp

>AT155433 NZ_CP068801:c4666747-4666496 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S4UDK5

Antitoxin

Source ID Structure
AlphaFold DB A0A0S4UDK3

References