Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/COG3657-dnstrm_HI1420
Location 65813..66342 Replicon plasmid Plas1
Accession NZ_CP052071
Organism Ralstonia solanacearum strain FJAT454.F1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HI822_RS18975 Protein ID WP_016722340.1
Coordinates 66115..66342 (-) Length 76 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HI822_RS18970 Protein ID WP_016722339.1
Coordinates 65813..66118 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HI822_RS18940 60917..61198 - 282 WP_016722336.1 hypothetical protein -
HI822_RS18945 61329..61613 - 285 WP_011003391.1 hypothetical protein -
HI822_RS18950 62065..63051 + 987 WP_016721870.1 IS5 family transposase -
HI822_RS18955 63196..63347 + 152 Protein_58 IS5/IS1182 family transposase -
HI822_RS18960 63514..64182 + 669 WP_038938024.1 hypothetical protein -
HI822_RS18965 64287..65600 - 1314 WP_038938025.1 metabolite/H+ symporter -
HI822_RS18970 65813..66118 - 306 WP_016722339.1 putative addiction module antidote protein Antitoxin
HI822_RS18975 66115..66342 - 228 WP_016722340.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HI822_RS18980 66497..67696 - 1200 WP_016726513.1 MFS transporter -
HI822_RS18985 67823..68644 - 822 WP_011003398.1 GntR family transcriptional regulator -
HI822_RS18990 68822..69373 - 552 WP_016722343.1 helix-turn-helix transcriptional regulator -
HI822_RS18995 69506..70105 + 600 WP_016722344.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cyaB / flgC / flgG / fliM / fliG / fliI / acrB / adeG / cheY / cheB / cheW / motA 1..2074832 2074832
- flank IS/Tn - - 62065..63051 986


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-67)

Antitoxin

Cro/C1-type helix-turn-helix domain

(52-96)


Sequences

Toxin        


Download         Length: 76 a.a.        Molecular weight: 8566.85 Da        Isoelectric Point: 7.2789

>T155429 WP_016722340.1 NZ_CP052071:c66342-66115 [Ralstonia solanacearum]
VRIDRLQMGHPGNMKAVRDGIRELRIDHGPGDRLYFVRHGVVLIVLLCGGDKSTQETDIRRAIDLSRRLDVDDME

Download         Length: 228 bp

>T155429 NZ_CP068801:c4482294-4482085 [Escherichia coli]
ATGGTTGATTATCCAAAACGTGATGCTATTTCCAACATCAACGCTATAATTGTAGATACATTTTTGTATATACAATTAGG
GATGGCAACTATGCCAATGGAGTTTGAATGGAATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTG
AAGATGCGGTGTTAGTGCTTGATGATCCACAACGAACGGAGCCGCTATGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10967.57 Da        Isoelectric Point: 7.2780

>AT155429 WP_016722339.1 NZ_CP052071:c66118-65813 [Ralstonia solanacearum]
MTMAQRTIKTRPWDSAEHLRTEADIAAYLDACLEEAGDDPAFITHALGVVARSRGMTQLARETGMTREGLYKALSEGGNP
SFATVLKVIRALGIRLHAVPT

Download         Length: 306 bp

>AT155429 NZ_CP068801:c4482088-4481786 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGTGCTGGCGAA
CAAATTCGACGAGGATATTGATTACAGCGACATCCCATCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References