Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/COG3657-dnstrm_HI1420
Location 50749..51278 Replicon plasmid Plas1
Accession NZ_CP052069
Organism Ralstonia solanacearum strain FJAT91.F50

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HI824_RS18440 Protein ID WP_016722340.1
Coordinates 51051..51278 (-) Length 76 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HI824_RS18435 Protein ID WP_016722339.1
Coordinates 50749..51054 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HI824_RS18405 46249..46734 + 486 WP_016726511.1 hypothetical protein -
HI824_RS18410 47065..47346 - 282 WP_016722336.1 hypothetical protein -
HI824_RS18415 47477..47761 - 285 WP_011003391.1 hypothetical protein -
HI824_RS18420 48066..48283 + 218 Protein_45 transposase -
HI824_RS18425 48450..49118 + 669 WP_038938024.1 hypothetical protein -
HI824_RS18430 49223..50536 - 1314 WP_038938025.1 metabolite/H+ symporter -
HI824_RS18435 50749..51054 - 306 WP_016722339.1 putative addiction module antidote protein Antitoxin
HI824_RS18440 51051..51278 - 228 WP_016722340.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HI824_RS18445 51433..52632 - 1200 WP_016726513.1 MFS transporter -
HI824_RS18450 52759..53580 - 822 WP_011003398.1 GntR family transcriptional regulator -
HI824_RS18455 53758..54309 - 552 WP_016722343.1 helix-turn-helix transcriptional regulator -
HI824_RS18460 54442..55041 + 600 WP_016722344.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cyaB / flgC / flgG / fliM / fliG / fliI / acrB / htpB / adeG / cheY / cheB / cheW / motA 1..2000885 2000885
- flank IS/Tn - - 45049..46014 965


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-67)

Antitoxin

Cro/C1-type helix-turn-helix domain

(52-96)


Sequences

Toxin        


Download         Length: 76 a.a.        Molecular weight: 8566.85 Da        Isoelectric Point: 7.2789

>T155425 WP_016722340.1 NZ_CP052069:c51278-51051 [Ralstonia solanacearum]
VRIDRLQMGHPGNMKAVRDGIRELRIDHGPGDRLYFVRHGVVLIVLLCGGDKSTQETDIRRAIDLSRRLDVDDME

Download         Length: 228 bp

>T155425 NZ_CP068801:3418199-3418585 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10967.57 Da        Isoelectric Point: 7.2780

>AT155425 WP_016722339.1 NZ_CP052069:c51054-50749 [Ralstonia solanacearum]
MTMAQRTIKTRPWDSAEHLRTEADIAAYLDACLEEAGDDPAFITHALGVVARSRGMTQLARETGMTREGLYKALSEGGNP
SFATVLKVIRALGIRLHAVPT

Download         Length: 306 bp

>AT155425 NZ_CP068801:3418575-3418904 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References