Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4998178..4998797 Replicon chromosome
Accession NZ_CP052036
Organism Klebsiella pneumoniae strain KPN41053

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HH204_RS24075 Protein ID WP_002892050.1
Coordinates 4998579..4998797 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HH204_RS24070 Protein ID WP_002892066.1
Coordinates 4998178..4998552 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HH204_RS24060 4993330..4994523 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HH204_RS24065 4994546..4997692 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HH204_RS24070 4998178..4998552 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HH204_RS24075 4998579..4998797 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HH204_RS24080 4998956..4999522 + 567 WP_002892030.1 maltose O-acetyltransferase -
HH204_RS24085 4999494..4999634 - 141 WP_004147370.1 hypothetical protein -
HH204_RS24090 4999655..5000125 + 471 WP_002892026.1 YlaC family protein -
HH204_RS24095 5000100..5001551 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HH204_RS24100 5001652..5002350 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
HH204_RS24105 5002347..5002487 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HH204_RS24110 5002487..5002750 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T155416 WP_002892050.1 NZ_CP052036:4998579-4998797 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T155416 NZ_CP068801:2043300-2043554 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT155416 WP_002892066.1 NZ_CP052036:4998178-4998552 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT155416 NZ_CP068801:2043052-2043303 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References