155399

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 2621202..2621697 Replicon chromosome
Accession NZ_CP052033
Organism Streptomyces collinus strain L2

Toxin (Protein)


Gene name relE Uniprot ID S5VLW5
Locus tag HGI09_RS11265 Protein ID WP_020941979.1
Coordinates 2621464..2621697 (+) Length 78 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S5UWF1
Locus tag HGI09_RS11260 Protein ID WP_019434848.1
Coordinates 2621202..2621471 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGI09_RS11250 (HGI09_22530) 2617185..2620181 - 2997 WP_020941981.1 BTAD domain-containing putative transcriptional regulator -
HGI09_RS11255 (HGI09_22540) 2620571..2621084 + 514 Protein_2229 Uma2 family endonuclease -
HGI09_RS11260 (HGI09_22550) 2621202..2621471 + 270 WP_019434848.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HGI09_RS11265 (HGI09_22560) 2621464..2621697 + 234 WP_020941979.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HGI09_RS11270 (HGI09_22570) 2621782..2622870 - 1089 WP_020941978.1 redox-regulated ATPase YchF -
HGI09_RS11275 (HGI09_22580) 2623051..2623596 + 546 WP_193384489.1 hypothetical protein -
HGI09_RS11280 (HGI09_22590) 2623609..2624361 - 753 WP_020941976.1 ROK family protein -
HGI09_RS11285 (HGI09_22600) 2624426..2625451 - 1026 WP_106960598.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
HGI09_RS11290 2625783..2625965 + 183 WP_020941974.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-77)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-58)


Sequences

Toxin        


Download         Length: 78 a.a.        Molecular weight: 8929.35 Da        Isoelectric Point: 10.1504

>T155399 WP_020941979.1 NZ_CP052033:2621464-2621697 [Streptomyces collinus]
VSEYRTVFRPEAQAELRKIPRDMALRILAKLTVLETDPLGFNTTALVSQPERRRLRVGDYRVVYTIDNGELVVWVAR

Download         Length: 234 bp

>T155399 NZ_CP068800:4459765-4460022 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGCCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10227.65 Da        Isoelectric Point: 4.6265

>AT155399 WP_019434848.1 NZ_CP052033:2621202-2621471 [Streptomyces collinus]
VTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKEVAAVVSIEVLRKYQEWEEREINRIIDERMANPAPGIPIEDI
MRETLARGE

Download         Length: 270 bp

>AT155399 NZ_CP068800:4460034-4460585 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCGACCTTCAAAGGAGAAATGGATTCACCGCTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S5VLW5

Antitoxin

Source ID Structure
AlphaFold DB S5UWF1

References