Detailed information of TA system TA155399

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 2621202..2621697
• Replicon: chromosome
• Accession: NZ_CP052033
• Organism: Streptomyces collinus strain L2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S5VLW5
• Locus tag: HGI09_RS11265
• Protein ID: WP_020941979.1
• Coordinates: 2621464..2621697 (+)
• Length: 78 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: S5UWF1
• Locus tag: HGI09_RS11260
• Protein ID: WP_019434848.1
• Coordinates: 2621202..2621471 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGI09_RS11250 (HGI09_22530)	2617185..2620181	-	2997	WP_020941981.1	BTAD domain-containing putative transcriptional regulator	-
HGI09_RS11255 (HGI09_22540)	2620571..2621084	+	514	Protein_2229	Uma2 family endonuclease	-
HGI09_RS11260 (HGI09_22550)	2621202..2621471	+	270	WP_019434848.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HGI09_RS11265 (HGI09_22560)	2621464..2621697	+	234	WP_020941979.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HGI09_RS11270 (HGI09_22570)	2621782..2622870	-	1089	WP_020941978.1	redox-regulated ATPase YchF	-
HGI09_RS11275 (HGI09_22580)	2623051..2623596	+	546	WP_193384489.1	hypothetical protein	-
HGI09_RS11280 (HGI09_22590)	2623609..2624361	-	753	WP_020941976.1	ROK family protein	-
HGI09_RS11285 (HGI09_22600)	2624426..2625451	-	1026	WP_106960598.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
HGI09_RS11290	2625783..2625965	+	183	WP_020941974.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-77)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-58)

Sequences

Toxin

Protein

• Length: 78 a.a.
• Molecular weight: 8929.35 Da
• Isoelectric Point: 10.1504

>T155399 WP_020941979.1 NZ_CP052033:2621464-2621697 [Streptomyces collinus]
VSEYRTVFRPEAQAELRKIPRDMALRILAKLTVLETDPLGFNTTALVSQPERRRLRVGDYRVVYTIDNGELVVWVAR

Nucleotide

• Length: 234 bp

>T155399 NZ_CP068800:4459765-4460022 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGCCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10227.65 Da
• Isoelectric Point: 4.6265

>AT155399 WP_019434848.1 NZ_CP052033:2621202-2621471 [Streptomyces collinus]
VTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKEVAAVVSIEVLRKYQEWEEREINRIIDERMANPAPGIPIEDI
MRETLARGE

Nucleotide

• Length: 270 bp

>AT155399 NZ_CP068800:4460034-4460585 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCGACCTTCAAAGGAGAAATGGATTCACCGCTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: S5VLW5

Antitoxin

• AlphaFold DB: S5UWF1