Detailed information of TA system TA155398

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 4570930..4571425
• Replicon: chromosome
• Accession: NZ_CP052032
• Organism: Streptomyces collinus strain SQ

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S5VLW5
• Locus tag: HGI10_RS20765
• Protein ID: WP_020941979.1
• Coordinates: 4570930..4571163 (-)
• Length: 78 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: S5UWF1
• Locus tag: HGI10_RS20770
• Protein ID: WP_019434848.1
• Coordinates: 4571156..4571425 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGI10_RS20740	4566662..4566844	-	183	WP_020941974.1	hypothetical protein	-
HGI10_RS20745 (HGI10_41520)	4567176..4568201	+	1026	WP_106960598.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
HGI10_RS20750 (HGI10_41530)	4568266..4569018	+	753	WP_020941976.1	ROK family protein	-
HGI10_RS20755 (HGI10_41540)	4569031..4569576	-	546	WP_193384489.1	hypothetical protein	-
HGI10_RS20760 (HGI10_41550)	4569757..4570845	+	1089	WP_020941978.1	redox-regulated ATPase YchF	-
HGI10_RS20765 (HGI10_41560)	4570930..4571163	-	234	WP_020941979.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HGI10_RS20770 (HGI10_41570)	4571156..4571425	-	270	WP_019434848.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HGI10_RS20775 (HGI10_41580)	4571543..4572056	-	514	Protein_4079	Uma2 family endonuclease	-
HGI10_RS20780 (HGI10_41590)	4572488..4575442	+	2955	WP_268825447.1	BTAD domain-containing putative transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-77)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-58)

Sequences

Toxin

Protein

• Length: 78 a.a.
• Molecular weight: 8929.35 Da
• Isoelectric Point: 10.1504

>T155398 WP_020941979.1 NZ_CP052032:c4571163-4570930 [Streptomyces collinus]
VSEYRTVFRPEAQAELRKIPRDMALRILAKLTVLETDPLGFNTTALVSQPERRRLRVGDYRVVYTIDNGELVVWVAR

Nucleotide

• Length: 234 bp

>T155398 NZ_CP068800:c4416598-4416389 [Escherichia coli]
ATGGTTGATTATCCAAAACGTGATGCTATTTCCAACATCAACGCTATAATTGTAGATACATTTTTGTATATACAATTAGG
GATGGCAACTATGCCAATGGAGTTTGAATGGAATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTG
AAGATGCGGTGTTAGTGCTTGATGATCCACAACGAACGGAGCCGCTATGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10227.65 Da
• Isoelectric Point: 4.6265

>AT155398 WP_019434848.1 NZ_CP052032:c4571425-4571156 [Streptomyces collinus]
VTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKEVAAVVSIEVLRKYQEWEEREINRIIDERMANPAPGIPIEDI
MRETLARGE

Nucleotide

• Length: 270 bp

>AT155398 NZ_CP068800:c4416392-4416090 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGTGCTGGCGAA
CAAATTCGACGAGGATATTGATTACAGCGACATCCCATCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Structures

Toxin

• AlphaFold DB: S5VLW5

Antitoxin

• AlphaFold DB: S5UWF1